Kao J H, Chen P J, Lai M Y, Chen W, Chen D S
Department of Internal Medicine, National Taiwan University College of Medicine, Taipei.
Arch Virol. 1998;143(4):797-802. doi: 10.1007/s007050050331.
We found that patients with dual HBV and GBV-C/HGV infection had comparable serum HBV DNA positivity and mean virus concentration compared with age-matched HBV carriers, and those with triple infection had a significantly lower HBV DNA positivity. Serum HCV RNA positivity and mean virus titer were similar between HCV carriers with or without GBV-C/HGV co-infection, and those with GBV-C/HGV co-infection seemed to have a lower serum ALT level. These data suggest that GBV-C/HGV infection exerts no significant suppression on levels of chronic hepatitis B or hepatitis C viremia.
我们发现，与年龄匹配的乙肝病毒携带者相比，乙肝病毒与GBV-C/HGV双重感染患者的血清乙肝病毒DNA阳性率和平均病毒浓度相当，而三重感染患者的乙肝病毒DNA阳性率则显著较低。在合并或未合并GBV-C/HGV感染的丙肝病毒携带者中，血清丙肝病毒RNA阳性率和平均病毒滴度相似，而合并GBV-C/HGV感染的患者血清谷丙转氨酶水平似乎较低。这些数据表明，GBV-C/HGV感染对慢性乙型肝炎或丙型肝炎病毒血症水平没有显著抑制作用。
