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用N-亚硝基二甲胺（NDMA）或二硝基氯苯（DNCB）致敏的人体中的半抗原特异性淋巴细胞转化

Hapten-specific lymphocyte transformation in humans sensitized with NDMA or DNCB.

作者信息

Andersen V

出版信息

Clin Exp Immunol. 1976 Sep;25(3):490-2.

PMID:963911
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541412/
Abstract

The primary immune response to a contact sensitizing dose of para-N-dimethylnitrosaniline (NDMA) and dinitrochlorobenzene (DNCB) was obtained in humans and measured in vitro by increased thymidine incorporation into sensitized lymphocytes. No cross-reaction was found between these two haptens, and it is thus possible on two separate occasions to quantify and follow the primary cellular immune response in man.

摘要

对接触致敏剂量的对 - N - 二甲基亚硝基苯胺（NDMA）和二硝基氯苯（DNCB）的初次免疫反应在人体中获得，并通过将胸苷掺入致敏淋巴细胞的量增加来进行体外测量。在这两种半抗原之间未发现交叉反应，因此有可能在两个不同的场合对人体的初次细胞免疫反应进行定量和跟踪。

相似文献

1
Hapten-specific lymphocyte transformation in humans sensitized with NDMA or DNCB.用N-亚硝基二甲胺（NDMA）或二硝基氯苯（DNCB）致敏的人体中的半抗原特异性淋巴细胞转化
Clin Exp Immunol. 1976 Sep;25(3):490-2.
2
Hapten-cell conjugates in DNCB contact sensitivity. In vitro stimulation with DNP-conjugates optimally inducing contact sensitivity in vivo.二硝基氯苯接触敏感性中的半抗原-细胞缀合物。用二硝基苯基缀合物进行体外刺激可在体内最佳地诱导接触敏感性。
Immunology. 1980 Feb;39(2):291-9.
3
Lymphocyte transformation during dinitrochlorobenzene contact sensitization. An in vitro and in vivo evaluation of the primary immune response in man.二硝基氯苯接触致敏期间的淋巴细胞转化。人体初次免疫反应的体外和体内评估。
J Clin Invest. 1973 Aug;52(8):1925-30. doi: 10.1172/JCI107376.
4
Specific blastogenesis and lymphokine production in DNCB-sensitive human leucocyte cultures stimulated with soluble and particulate DNP-containing antigens.用可溶性和颗粒性含二硝基苯基（DNP）抗原刺激二硝基氯苯（DNCB）敏感的人白细胞培养物时的特异性母细胞生成和淋巴因子产生。
Clin Exp Immunol. 1976 Mar;23(3):481-90.
5
Anti-dinitrophenyl antibody production in strain 13 guinea pigs fed or sensitized with dinitrochlorobenzene.用二硝基氯苯喂养或致敏的13号品系豚鼠中抗二硝基苯基抗体的产生。
J Immunol. 1975 Feb;114(2 pt 2):863-71.
6
Sensitivity to the weed killer DNA-nitralin and cross-sensitivity to dinitrochlorobenzene.对除草剂DNA-硝草胺的敏感性及对二硝基氯苯的交叉敏感性。
Arch Dermatol. 1983 Apr;119(4):304-6.
7
Immunological studies in psoriasis. The quantitative evaluation of cell-mediated immunity in patients with psoriasis by experimental sensitization to 2,4-dinitrochlorobenzene.银屑病的免疫学研究。通过对2,4-二硝基氯苯进行实验性致敏来定量评估银屑病患者的细胞介导免疫。
Dermatologica. 1977;155(1):13-25.
8
[The possible evaluation of immunity with the DNCB skin test in relation to blast transformation of lymphocytes].[用二硝基氯苯皮肤试验评估免疫功能与淋巴细胞转化的关系]
Minerva Med. 1982 Oct 27;73(41):2891-5.
9
HLA-D restriction of the proliferative response to hapten dinitrophenyl-conjugated cells. I. No indication of cross-reaction between dinitrophenyl-conjugated autologous and nonconjugated allogeneic cells.对半抗原二硝基苯基偶联细胞增殖反应的HLA - D限制。I. 二硝基苯基偶联的自体细胞与未偶联的同种异体细胞之间无交叉反应迹象。
J Exp Med. 1980 Aug 1;152(2 Pt 2):256s-269s.
10
[Suppression of DNCB contact hypersensitivity by anti-hapten-antibody (author's transl)].抗半抗原抗体对二硝基氯苯接触性超敏反应的抑制作用（作者译）
Nihon Hifuka Gakkai Zasshi. 1977 Jun 20;87(7):411-7.

本文引用的文献

1
Lymphocyte transformation in contact sensitivity.接触敏感性中的淋巴细胞转化
Immunology. 1970 Aug;19(2):189-203.
2
Studies on the contact sensitization of man with simple chemicals. I. Specific lymphocyte transformation in response to dinitrochlorobenzene sensitization.人体对简单化学物质的接触致敏研究。I. 对二硝基氯苯致敏的特异性淋巴细胞转化
J Invest Dermatol. 1973 Nov;61(5):261-9. doi: 10.1111/1523-1747.ep12676486.
3
The role of the afferent lymph in the induction of contact sensitivity.传入淋巴在接触敏感性诱导中的作用。
Adv Exp Med Biol. 1976;66:191-6. doi: 10.1007/978-1-4613-4355-4_29.