Sadeh A, Horowitz I, Wolach-Benodis L, Wolach B
Department of Psychology, Tel Aviv University, Israel.
Sleep. 1998 Jun 15;21(4):379-84. doi: 10.1093/sleep/21.4.379.
The aim of this study was to assess sleep and pulmonary function in asthmatic and control children. Forty children with well-controlled, stable asthma, and 34 controls (age range: 8.2 to 15.4 years) were monitored with wrist actigraphs and peak-flow meters for 3 consecutive days. In addition, asthma severity was assessed by subjective parental and self-rating scale and symptom checklist. Asthmatic children had poorer sleep quality in comparison to their controls, as manifested in lower percentages of quiet sleep (p < .05) and increased activity level during sleep (p < .05). As expected, asthmatic children had reduced morning peak expiratory flow measures (p < .01) and a higher evening-to-morning drop in peak expiratory flow (p < .005). Peak-flow measures were significantly correlated with subjective and objective sleep measures. In the asthmatic group, sleep measures were also correlated with subjective asthma severity indices and symptom checklists. We conclude that poorer sleep is associated with reduced pulmonary function. The reduced sleep quality, coupled with subjective reports of increased fatigue and reduced alertness found in asthmatic children, suggest that these children are at risk for developing neurobehavioral deficits associated with chronic sleep loss.
本研究旨在评估哮喘患儿和对照儿童的睡眠及肺功能。40名哮喘控制良好、病情稳定的儿童以及34名对照儿童（年龄范围：8.2至15.4岁）连续3天使用腕部活动记录仪和峰值流量计进行监测。此外，通过家长主观评分量表、自我评分量表和症状清单评估哮喘严重程度。与对照儿童相比，哮喘患儿的睡眠质量较差，表现为安静睡眠百分比更低（p < .05）以及睡眠期间活动水平增加（p < .05）。正如预期的那样，哮喘患儿早晨的呼气峰值流量测量值降低（p < .01），呼气峰值流量的夜间至早晨下降幅度更大（p < .005）。峰值流量测量值与主观和客观睡眠测量值显著相关。在哮喘组中，睡眠测量值也与主观哮喘严重程度指标和症状清单相关。我们得出结论，较差的睡眠与肺功能下降有关。睡眠质量下降，再加上哮喘患儿中发现的疲劳增加和警觉性降低的主观报告，表明这些儿童有出现与慢性睡眠不足相关的神经行为缺陷的风险。
