一只患有致死性脑膜脑炎的犬的博尔纳病
Borna disease in a dog with lethal meningoencephalitis.
作者信息
Weissenböck H, Nowotny N, Caplazi P, Kolodziejek J, Ehrensperger F
机构信息
Institute of Pathology and Forensic Veterinary Medicine, University of Veterinary Medicine, Vienna, Austria.
出版信息
J Clin Microbiol. 1998 Jul;36(7):2127-30. doi: 10.1128/JCM.36.7.2127-2130.1998.
Abstract
A dog was euthanatized because of progressive neurological signs. Histologically, a nonsuppurative meningoencephalitis was found. By immunohistochemistry, in situ hybridization, and nested PCR procedures, Borna disease virus (BDV) antigen and BDV-specific RNA were demonstrated in brain tissues of the dog. The nucleotide sequence of the PCR product showed 94 to 98% homology to published BDV sequences. This is the first description of Borna disease in a dog.
摘要
一只狗因进行性神经症状而被实施安乐死。组织学检查发现非化脓性脑膜脑炎。通过免疫组织化学、原位杂交和巢式PCR程序，在该犬的脑组织中检测到博尔纳病病毒（BDV）抗原和BDV特异性RNA。PCR产物的核苷酸序列与已发表的BDV序列显示出94%至98%的同源性。这是犬博尔纳病的首次报道。
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