Caplazi P, Waldvogel A, Stitz L, Braun U, Ehrensperger F
Institut fuer Veterinaerpathologie, Universitaet Zurich, Switzerland.
J Comp Pathol. 1994 Jul;111(1):65-72. doi: 10.1016/s0021-9975(05)80112-4.
Based on the immunohistochemical demonstration of viral antigen and on the histological brain lesions, Borna disease was diagnosed in a cow and a bull which had suffered from a severe, subacute progressive disorder of the central nervous system. Virus-specific antigen was characteristically localized in neurons, predominantly in the perikaryon and dendrites. In a serum sample available from one of the animals a Borna disease virus antibody titre of 1 in 80 was demonstrated. This is the first report of the natural disease in cattle.
基于病毒抗原的免疫组化证明以及脑组织病变，在一头患有严重亚急性进行性中枢神经系统疾病的母牛和一头公牛身上诊断出博尔纳病。病毒特异性抗原特征性地定位于神经元中，主要在胞体和树突中。在其中一只动物的血清样本中，检测到博尔纳病病毒抗体滴度为1:80。这是牛自然感染该病的首例报告。
