Ingham P W
Developmental Genetics Programme, The Krebs Institute, University of Sheffield, United Kingdom.
Int J Dev Biol. 1998;42(3):423-9.
Animals homozygous for a spontaneously arising allele of the trithorax (trx) gene exhibit highly variegated homoeotic transformations of their thoracic and abdominal segments. This paper retraces the sometimes tortuous history of the analysis of trx function, from the fortuitous recovery of the first trx allele, to the present understanding that trx encodes a highly conserved chromatin binding protein that is required to maintain the expression of the Antennapedia and Bithorax complex genes.
三体胸节（trx）基因自发产生的等位基因的纯合动物，其胸段和腹段表现出高度斑驳的同源异型转化。本文追溯了trx功能分析有时曲折的历史，从第一个trx等位基因的偶然发现，到目前的认识，即trx编码一种高度保守的染色质结合蛋白，该蛋白是维持触角足和双胸复合体基因表达所必需的。
