Heys S D, Walker L G, Deehan D J, Eremin O E
Surgical Nutrition and Metabolism Unit, University of Aberdeen, UK.
J R Coll Surg Edinb. 1998 Jun;43(3):163-8.
Various prognostic factors for survival have been identified in patients with colorectal cancer. However, although it has been suggested that the pre-treatment serum albumin concentration is a prognostic indicator in certain malignant diseases (melanoma, prostate cancer, leukaemia), its value in patients with colorectal cancer remains unclear. This study investigated the prognostic value of serum albumin in this patient group. A total of 431 patients presenting to the Professorial Surgical Unit between 1972 and 1985 were analysed in this study. Using the Cox proportional hazard model, age, tumour stage (Dukes' stage) and tumour differentiation were shown to be independent prognostic factors for survival in patients with localized colorectal cancer. In addition, the pre-treatment serum albumin concentration was found to be an independent prognostic indicator. This is the first such documentation for patients with 'curable' colorectal cancer.
已确定了结直肠癌患者的各种生存预后因素。然而，尽管有人提出治疗前血清白蛋白浓度是某些恶性疾病（黑色素瘤、前列腺癌、白血病）的预后指标，但其在结直肠癌患者中的价值仍不明确。本研究调查了血清白蛋白在该患者群体中的预后价值。本研究分析了1972年至1985年间在教授级外科病房就诊的431例患者。使用Cox比例风险模型，年龄、肿瘤分期（Dukes分期）和肿瘤分化被证明是局限性结直肠癌患者生存的独立预后因素。此外，治疗前血清白蛋白浓度被发现是一个独立的预后指标。这是首次针对“可治愈”结直肠癌患者的此类记录。
