金黄色葡萄球菌毒力调节因子Agr和Sar在曲拉通X-100和青霉素诱导的自溶中的相反作用。
Opposing roles of the Staphylococcus aureus virulence regulators, Agr and Sar, in Triton X-100- and penicillin-induced autolysis.
作者信息
Fujimoto D F, Bayles K W
机构信息
Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow, Idaho 83844-3052, USA.
出版信息
J Bacteriol. 1998 Jul;180(14):3724-6. doi: 10.1128/JB.180.14.3724-3726.1998.
Abstract
The regulation of murein hydrolases is a critical aspect of peptidoglycan growth and metabolism. In the present study, we demonstrate that mutations within the Staphylococcus aureus virulence factor regulatory genes, agr and sar, affect autolysis, resulting in decreased and increased autolysis rates, respectively. Zymographic analyses of these mutant strains suggest that agr and sar exert their effects on autolysis, in part, by modulating murein hydrolase expression and/or activity.
摘要
胞壁质水解酶的调控是肽聚糖生长和代谢的关键方面。在本研究中，我们证明金黄色葡萄球菌毒力因子调控基因agr和sar内的突变会影响自溶，分别导致自溶率降低和升高。对这些突变菌株的酶谱分析表明，agr和sar对自溶的影响部分是通过调节胞壁质水解酶的表达和/或活性来实现的。
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