Waberski T D, Buchner H, Lehnertz K, Hufnagel A, Fuchs M, Beckmann R, Rienäcker A
Dept. of Neurology, RWTH Aachen, Germany.
Brain Topogr. 1998 Summer;10(4):283-90. doi: 10.1023/a:1022275024069.
During the last decade multiple work has been done to determine the sources of epileptiform activity by means of dipole source localization based on recordings of the magnetoencephalogram (MEG) or the electroencephalogram (EEG). The actual available advanced volume conductor models and the multiple source reconstruction by regularization may give new impulse to EEG based source analyses in epilepsy patients. This study demonstrates the principal properties of these techniques. We applied two different EEG source reconstruction techniques within different volume conductor models to localize induced spike activity in a selected patient suffering from medically intractable temporal lobe epilepsy: 1) single moving dipole solution in a 3-shell spherical model versus individual head models (boundary-element-model, BEM, and finite-element-model, FEM); 2) a regularization technique for current density reconstructions using both BEM and FEM. When compared to findings of invasive recordings no adequate source locations were derived from the moving dipole solution in both the 3-shell head model and BEM. In contrast, a high congruence of source reconstruction and invasive determination of the focus was obtained using the regularization techniques in both BEM and FEM, indicating the high spatial accuracy of this technique in individual head models.
在过去十年中，人们开展了多项工作，通过基于脑磁图（MEG）或脑电图（EEG）记录的偶极子源定位来确定癫痫样活动的来源。实际可用的先进容积导体模型以及通过正则化进行的多源重建可能会为癫痫患者基于脑电图的源分析带来新的推动。本研究展示了这些技术的主要特性。我们在不同的容积导体模型中应用了两种不同的脑电图源重建技术，以定位一名患有药物难治性颞叶癫痫的选定患者的诱发性棘波活动：1）在三壳球形模型与个体头部模型（边界元模型，BEM，和有限元模型，FEM）中的单移动偶极子解；2）使用BEM和FEM进行电流密度重建的正则化技术。与侵入性记录的结果相比，在三壳头部模型和BEM中，移动偶极子解均未得出足够的源位置。相比之下，在BEM和FEM中使用正则化技术时，源重建与侵入性确定的病灶高度一致，表明该技术在个体头部模型中具有较高的空间准确性。
