巴西蜂胶的化学成分及其细胞毒性活性。
Chemical constituents of Brazilian propolis and their cytotoxic activities.
作者信息
Banskota A H, Tezuka Y, Prasain J K, Matsushige K, Saiki I, Kadota S
机构信息
Department of Natural Products Chemistry, Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toya.
出版信息
J Nat Prod. 1998 Jul;61(7):896-900. doi: 10.1021/np980028c.
The EtOAc-soluble fraction of the MeOH extract of propolis afforded a new prenylated chromane derivative, 3-hydroxy-2, 2-dimethyl-8-prenylchromane-6-propenoic acid (1), along with 22 known compounds, 2-23. Of the known compounds, 4, 7, 12-19, and 22 were isolated for the first time from propolis, and the absolute configuration of 23 was established as (2S,3R). Investigation suggested that Baccharis spp. are a significant source of tropical Brazilian propolis, in addition to Clusia minor, Clusia major, and Araucaria heterophylla. All the compounds were tested for their cytotoxicity toward human HT-1080 fibrosarcoma and murine colon 26-L5 carcinoma cells. Among these compounds, 9 and 19-21 showed potent cytotoxicity, having ED50 values equal to or less than 10 microg/mL.
蜂胶甲醇提取物的乙酸乙酯可溶部分得到一种新的异戊烯基化色满衍生物，3-羟基-2,2-二甲基-8-异戊烯基色满-6-丙烯酸（1），以及22种已知化合物（2 - 23）。在这些已知化合物中，4、7、12 - 19和22首次从蜂胶中分离得到，并且确定了23的绝对构型为(2S,3R)。研究表明，除了小克鲁西亚木、大克鲁西亚木和南洋杉外，酒神菊属植物是巴西热带蜂胶的重要来源。对所有化合物进行了针对人HT - 1080纤维肉瘤和小鼠结肠26 - L5癌细胞的细胞毒性测试。在这些化合物中，9和19 - 21表现出较强的细胞毒性，ED50值等于或小于10μg/mL。
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