南美蟛蜞菊镇痛成分的化学与药理学研究
Chemical and pharmacological examination of antinociceptive constituents of Wedelia paludosa.
作者信息
Block L C, Santos A R, de Souza M M, Scheidt C, Yunes R A, Santos M A, Monache F D, Filho V C
机构信息
Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí (UNIVALI), SC, Brazil.
出版信息
J Ethnopharmacol. 1998 May;61(1):85-9. doi: 10.1016/s0378-8741(98)00019-1.
The present work describes the antinociceptive effects of some fractions and two pure compounds obtained from the Wedelia paludosa, a Brazilian medicinal plant employed in folk medicine against a variety of diseases, including dolorous pathologies. It was found that such fractions as well as kaurenoic acid and luteolin exhibit marked antinociceptive action in mice using acetic acid-induced writhing. They were more active than some well-known analgesic drugs, such as acetyl salicylic acid, acetaminophen, dipyrone and indomethacin. The results confirm our previous studies conducted with this plant, suggesting that different chemical constituents are responsible for the antinociceptive activity shown by the extracts and fractions prepared from W. paludosa.
本研究描述了从巴西药用植物湿地威灵仙（Wedelia paludosa）中获得的一些提取物和两种纯化合物的抗伤害感受作用，该植物在民间医学中用于治疗多种疾病，包括疼痛性病症。研究发现，这些提取物以及贝壳杉烯酸和木犀草素在使用乙酸诱导扭体的小鼠中表现出显著的抗伤害感受作用。它们比一些知名的镇痛药，如乙酰水杨酸、对乙酰氨基酚、安乃近和吲哚美辛更具活性。这些结果证实了我们之前对该植物进行的研究，表明不同的化学成分是湿地威灵仙提取物和馏分所表现出的抗伤害感受活性的原因。
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