Tn5706，一种来自多杀巴斯德菌的介导四环素抗性的转座子样元件。
Tn5706, a transposon-like element from Pasteurella multocida mediating tetracycline resistance.
作者信息
Kehrenberg C, Werckenthin C, Schwarz S
机构信息
Institut für Tierzucht und Tierverhalten der Bundesforschungsanstalt für Landwirtschaft Braunschweig-Völkenrode, 29223 Celle, Germany.
出版信息
Antimicrob Agents Chemother. 1998 Aug;42(8):2116-8. doi: 10.1128/AAC.42.8.2116.
Abstract
The 4,378-bp putative tetracycline resistance transposon Tn5706 of Pasteurella multocida consists of an internal tet(H)-tetR resistance gene region which is flanked by almost identical insertion elements, IS1596 and IS1597. Two reading frames for proteins of 70 and 228 amino acids were detected in each of these insertion sequence elements. The 228-amino-acid protein revealed homology to transposase proteins of gram-positive bacteria.
摘要
多杀巴斯德氏菌的4378碱基对推定四环素抗性转座子Tn5706由一个内部tet(H)-tetR抗性基因区域组成，该区域两侧是几乎相同的插入元件IS1596和IS1597。在这些插入序列元件的每一个中都检测到了两个分别编码70和228个氨基酸的蛋白质的阅读框。这种228个氨基酸的蛋白质与革兰氏阳性菌的转座酶蛋白具有同源性。
相似文献
1
Tn5706, a transposon-like element from Pasteurella multocida mediating tetracycline resistance.
Antimicrob Agents Chemother. 1998 Aug;42(8):2116-8. doi: 10.1128/AAC.42.8.2116.
2
Identification of a truncated, but functionally active tet(H) tetracycline resistance gene in Pasteurella aerogenes and Pasteurella multocida.
FEMS Microbiol Lett. 2000 Jul 15;188(2):191-5. doi: 10.1111/j.1574-6968.2000.tb09192.x.
3
The transposon-like structure of IS26-tetracycline, and kanamycin resistance determinant derived from transferable R plasmid of fish pathogen, Pasteurella piscicida.
Microbiol Immunol. 1994;38(1):31-8. doi: 10.1111/j.1348-0421.1994.tb01741.x.
4
A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline.
Antimicrob Agents Chemother. 1993 Dec;37(12):2699-705. doi: 10.1128/AAC.37.12.2699.
5
Distribution of tet(H) among Pasteurella isolates from the United States and Canada.
Antimicrob Agents Chemother. 1996 Jun;40(6):1558-60. doi: 10.1128/AAC.40.6.1558.
6
Diversity of tetracycline resistance genes in bacteria from Chilean salmon farms.
Antimicrob Agents Chemother. 2003 Mar;47(3):883-8. doi: 10.1128/AAC.47.3.883-888.2003.
7
Tetracycline resistance genes in isolates of Pasteurella multocida, Mannheimia haemolytica, Mannheimia glucosida and Mannheimia varigena from bovine and swine respiratory disease: intergeneric spread of the tet(H) plasmid pMHT1.
J Antimicrob Chemother. 2001 Nov;48(5):631-40. doi: 10.1093/jac/48.5.631.
8
Genetic and phenotypic characterization of tetracycline-resistant Pasteurella multocida isolated from pigs.
Vet Microbiol. 2019 Jun;233:159-163. doi: 10.1016/j.vetmic.2019.05.001. Epub 2019 May 2.
9
Tetracycline resistance determinants, Tet B and Tet M, detected in Pasteurella haemolytica and Pasteurella multocida from bovine herds.
J Antimicrob Chemother. 1995 Nov;36(5):815-9. doi: 10.1093/jac/36.5.815.
10
New plasmid-borne antibiotic resistance gene cluster in Pasteurella multocida.
Antimicrob Agents Chemother. 2003 Sep;47(9):2978-80. doi: 10.1128/AAC.47.9.2978-2980.2003.
引用本文的文献
1
Integrative and conjugative elements associated with antimicrobial resistance in multidrug resistant isolates from bovine respiratory disease (BRD)-affected animals in Spanish feedlots.
Vet Q. 2025 Dec;45(1):1-15. doi: 10.1080/01652176.2025.2474220. Epub 2025 Mar 8.
2
Antibacterial Activity of Microbial Natural Products against Bacterial Pathogens of Veterinary and Zoonotic Relevance.
Antibiotics (Basel). 2024 Jan 30;13(2):135. doi: 10.3390/antibiotics13020135.
3
A Sensitive and Accurate Recombinase Polymerase Amplification Assay for Detection of the Primary Bacterial Pathogens Causing Bovine Respiratory Disease.
Front Vet Sci. 2020 Apr 22;7:208. doi: 10.3389/fvets.2020.00208. eCollection 2020.
4
Molecular characterization of Mannheimia haemolytica isolates associated with pneumonic cases of sheep in selected areas of Central Ethiopia.
BMC Microbiol. 2018 Dec 5;18(1):205. doi: 10.1186/s12866-018-1338-x.
5
Integrative Conjugative Element ICE1 Encodes for Antimicrobial Resistance and Metal Tolerance in .
Front Vet Sci. 2018 Jul 10;5:153. doi: 10.3389/fvets.2018.00153. eCollection 2018.
6
Antimicrobial Resistance in of Veterinary Origin.
Microbiol Spectr. 2018 May;6(3). doi: 10.1128/microbiolspec.ARBA-0022-2017.
7
Mechanisms of Bacterial Resistance to Antimicrobial Agents.
Microbiol Spectr. 2018 Jan;6(1). doi: 10.1128/microbiolspec.ARBA-0019-2017.
8
Diversity of the Tetracycline Mobilome within a Chinese Pig Manure Sample.
Appl Environ Microbiol. 2016 Oct 14;82(21):6454-6462. doi: 10.1128/AEM.01754-16. Print 2016 Nov 1.
9
Previously undescribed plasmids recovered from activated sludge confer tetracycline resistance and phenotypic changes to Acinetobacter oleivorans DR1.
Microb Ecol. 2014 Feb;67(2):369-79. doi: 10.1007/s00248-013-0343-8. Epub 2013 Dec 13.
10
Horizontal gene transfer in Histophilus somni and its role in the evolution of pathogenic strain 2336, as determined by comparative genomic analyses.
BMC Genomics. 2011 Nov 23;12:570. doi: 10.1186/1471-2164-12-570.
本文引用的文献
1
'Avirulence genes' in animal pathogens?
Trends Microbiol. 1998 Jan;6(1):3-6. doi: 10.1016/S0966-842X(97)01183-9.
2
Molecular characterization of the plasmid-encoded eps gene cluster essential for exopolysaccharide biosynthesis in Lactococcus lactis.
Mol Microbiol. 1997 Apr;24(2):387-97. doi: 10.1046/j.1365-2958.1997.3521720.x.
3
Distribution of tet(H) among Pasteurella isolates from the United States and Canada.
Antimicrob Agents Chemother. 1996 Jun;40(6):1558-60. doi: 10.1128/AAC.40.6.1558.
4
[Resistance pattern of bovine Pasteurella].
Berl Munch Tierarztl Wochenschr. 1996 May;109(5):168-71.
5
Tetracycline resistance determinants, Tet B and Tet M, detected in Pasteurella haemolytica and Pasteurella multocida from bovine herds.
J Antimicrob Chemother. 1995 Nov;36(5):815-9. doi: 10.1093/jac/36.5.815.
6
Two putative insertion sequences flank a truncated glycogen branching enzyme gene in the thermophile Bacillus stearothermophilus CU21.
DNA Seq. 1993;4(1):1-9. doi: 10.3109/10425179309015616.
7
A 4-year survey of antimicrobial susceptibility trends for isolates from cattle with bovine respiratory disease in North America.
J Clin Microbiol. 1994 Mar;32(3):725-31. doi: 10.1128/jcm.32.3.725-731.1994.
8
A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline.
Antimicrob Agents Chemother. 1993 Dec;37(12):2699-705. doi: 10.1128/AAC.37.12.2699.
9
The transposon-like structure of IS26-tetracycline, and kanamycin resistance determinant derived from transferable R plasmid of fish pathogen, Pasteurella piscicida.
Microbiol Immunol. 1994;38(1):31-8. doi: 10.1111/j.1348-0421.1994.tb01741.x.
10
Novel insertion sequence-like element IS982 in lactococci.
Plasmid. 1995 May;33(3):218-25. doi: 10.1006/plas.1995.1023.
Zotero 插件