一种来自多杀性巴氏杆菌的新型四环素抗性决定子Tet H，它能介导四环素的主动外排。
A new tetracycline resistance determinant, Tet H, from Pasteurella multocida specifying active efflux of tetracycline.
作者信息
Hansen L M, McMurry L M, Levy S B, Hirsh D C
机构信息
Department of Veterinary Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis 95616.
出版信息
Antimicrob Agents Chemother. 1993 Dec;37(12):2699-705. doi: 10.1128/AAC.37.12.2699.
Abstract
The tetracycline resistance determinant on plasmid pVM111 from an avian strain of Pasteurella multocida mediates tetracycline resistance by a regulated active efflux mechanism. DNA coding for the determinant did not hybridize at high stringency with DNA representing a group of common tetracycline resistance determinants. The DNA sequence, however; revealed a structural gene and a repressor gene which had significant (37 to 64%) sequence similarities with previously described classes of efflux-type tetracycline resistance genes from members of the family Enterobacteriaceae. The new determinant has been assigned to class H.
摘要
来自禽多杀性巴氏杆菌菌株的质粒pVM111上的四环素抗性决定簇通过一种受调控的主动外排机制介导四环素抗性。该决定簇的编码DNA在高严谨度下与代表一组常见四环素抗性决定簇的DNA不杂交。然而，DNA序列显示出一个结构基因和一个阻遏基因，它们与先前描述的肠杆菌科成员的外排型四环素抗性基因类别具有显著的（37%至64%）序列相似性。这个新的决定簇已被归为H类。
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