Blann A D, Lip G Y
University Department of Medicine, City Hospital, Birmingham, UK.
Blood Coagul Fibrinolysis. 1998 Jun;9(4):297-306.
Changes in endothelial cell physiology are now an accepted component of inflammatory and atherosclerotic vascular disease. This communication will review the scientific and clinical evidence that supports this statement, which may be demonstrated by in vivo arterial manipulations or by measuring plasma levels of endothelial cell-specific products. The former invasive approach has provided useful insights into the pharmacology of blood flow and blood pressure regulation whilst the latter has provided epidemiological evidence that endothelial cell injury can lead to an increased risk of morbidity and mortality. In addition, studies based on both techniques have demonstrated that treatment or reversal of the risk factors for atherosclerosis can be beneficial to the endothelium, validating the theory that the endothelium is the prime target for the disease process.
内皮细胞生理变化如今已被公认为是炎症性和动脉粥样硬化性血管疾病的一个组成部分。本交流将回顾支持这一观点的科学和临床证据，这些证据可通过体内动脉操作或测量内皮细胞特异性产物的血浆水平来证明。前一种侵入性方法为血流和血压调节的药理学提供了有用的见解，而后一种方法则提供了流行病学证据，表明内皮细胞损伤会导致发病和死亡风险增加。此外，基于这两种技术的研究均表明，治疗或逆转动脉粥样硬化的危险因素对内皮有益，这证实了内皮是疾病进程主要靶点的理论。
