Parameswaran K, Hildreth A J, Chadha D, Keaney N P, Taylor I K, Bansal S K
Department of Respiratory Medicine, City Hospitals NHS Trust, Sunderland, Tyne & Wear, U.K.
Respir Med. 1998 Mar;92(3):573-7. doi: 10.1016/s0954-6111(98)90311-0.
Bronchial asthma is now increasingly recognized in the elderly and is associated with significant morbidity and mortality. The aims of this study were two-fold: first, to assess the prevalence and, second, to evaluate diagnostic awareness, therapeutic management and patient perception of bronchial asthma among elderly patients in the community. From the age-sex register of an urban general practice in NE England, 2004 patients aged > 65 years were eligible for inclusion. Response to an initial screening questionnaire on respiratory symptomatology was 68% (n = 1362). Of these, 869 patients had respiratory symptoms: 390 voluntarily agreed to be evaluated further including assessment of airway physiology. In this group 369/390 had obstructive spirometry and, of these, 95 patients fulfilled clinical and physiological criteria of bronchial asthma. Prevalence of asthma within this age cohort was minimally and rather crudely assigned at 4.5% (95/2004). Among the 95 patients so-defined patients with asthma [age 70 +/- 8 years (mean +/- SD), FEV1 = 0.96 +/- 0.41, 33 male, 75 life-long non-smokers], subjective awareness, perception and attribution of pulmonary symptoms were poor. Further, despite tangible evidence of reversible and significant airflow limitation, only 21 were receiving inhaled glucocorticoid therapy (median daily dose 400 micrograms). Asthma in the elderly remains poorly perceived, poorly recognized and suboptimally treated. These findings are particularly apposite in the light of current epidemiological trends in asthma mortality and morbidity in elderly age cohorts.
支气管哮喘在老年人中越来越常见,且与较高的发病率和死亡率相关。本研究有两个目的:第一,评估患病率;第二,评估社区老年患者对支气管哮喘的诊断认知、治疗管理及患者感受。从英格兰东北部一个城市全科诊所的年龄-性别登记册中,筛选出2004名年龄大于65岁的患者纳入研究。对关于呼吸道症状的初始筛查问卷的回复率为68%(n = 1362)。其中,869名患者有呼吸道症状:390名患者自愿同意进一步评估,包括气道生理学评估。在这组患者中,369/390的患者肺功能呈阻塞性,其中95名患者符合支气管哮喘的临床和生理学标准。该年龄组中哮喘的患病率最低且粗略估计为4.5%(95/2004)。在这95名确诊为哮喘的患者中[年龄70±8岁(均值±标准差),第一秒用力呼气容积(FEV1)= 0.96±0.41,男性33名,75名终生不吸烟者],对肺部症状的主观认知、感受和归因较差。此外,尽管有明显的可逆性和显著气流受限的证据,但只有21名患者接受吸入糖皮质激素治疗(每日中位剂量400微克)。老年人中的哮喘仍然认知不足、诊断率低且治疗不充分。鉴于目前老年人群中哮喘死亡率和发病率的流行病学趋势,这些发现尤为恰当。