Muñoz S E, Navarro A, Lantieri M J, Fabro M E, Peyrano M G, Ferraroni M, Decarli A, La Vecchia C, Eynard A R
Instituto de Biologia Celular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.
Eur J Cancer Prev. 1998 Jun;7(3):207-13. doi: 10.1097/00008469-199806000-00005.
The relationship between social class indicators, body mass index (BMI), selected life-style habits (alcohol, coffee, maté and tea drinking) and colorectal cancer was investigated in a case-control study conducted between 1993 and 1997 in Córdoba, Argentina, a relatively high mortality area of colorectal cancer. Cases were 190 patients below age 80 years with incident, histologically confirmed colorectal adenocarcinomas, and controls were 393 patients admitted to hospital for a wide spectrum of acute, non-neoplastic disorders. Higher social class, based on occupation of the head of the household, was significantly associated with colorectal cancer risk: the odds ratios (OR) and 95% confidence intervals (95% CI) were 1.9 (1.2-2.9) for intermediate and 2.0 (1.2-3.4) for the highest as compared to the lowest social class individuals. When compared with subjects whose BMI was < 25 kg/m2, the OR was 1.1 (0.7-1.6) for those with BMI 25 to 29 kg/m2, and 1.3 (0.7-2.3) for those > or = 30. In comparison with alcohol abstainers, the OR was 2.8 (1.6-5.1) for drinkers, and there was a significant trend in risk with dose. The association was observed with wine (the most common alcoholic beverage in Argentina), as well as for beer and spirits. The consumption of coffee, maté and tea was not significantly related to colorectal cancer, but the ORs were below unity (0.9 (0.7-1.3) for coffee, 0.9 (0.6-1.2) for maté and 0.8 (0.6-1.2) for tea drinkers). The relationship between social class, alcohol drinking and colorectal cancer were consistent across strata of sex and age. This study confirms that colorectal cancer has positive social class correlates. The association with alcohol drinking is apparently stronger than previously reported, and may be due to the role of chance and/or peculiar correlates of alcohol drinking in this Argentinean population.
1993年至1997年在阿根廷科尔多瓦进行了一项病例对照研究，调查社会阶层指标、体重指数（BMI）、特定生活方式习惯（饮酒、喝咖啡、喝马黛茶和喝茶）与结直肠癌之间的关系。科尔多瓦是结直肠癌死亡率相对较高的地区。病例为190名80岁以下新诊断的、经组织学确诊的结直肠腺癌患者，对照为393名因各种急性非肿瘤性疾病入院的患者。根据户主职业划分的较高社会阶层与患结直肠癌风险显著相关：与社会阶层最低的个体相比，中层社会阶层的优势比（OR）和95%置信区间（95%CI）为1.9（1.2 - 2.9），最高层为2.0（1.2 - 3.4）。与BMI<25kg/m²的受试者相比，BMI为25至29kg/m²的受试者OR为1.1（0.7 - 1.6），BMI≥30的受试者OR为1.3（0.7 - 2.3）。与戒酒者相比，饮酒者的OR为2.8（1.6 - 5.1），且风险随饮酒量有显著趋势。观察到饮用葡萄酒（阿根廷最常见的酒精饮料）以及啤酒和烈酒均存在这种关联。喝咖啡、喝马黛茶和喝茶与结直肠癌无显著相关性，但OR均低于1（喝咖啡者为0.9（0.7 - 1.3），喝马黛茶者为0.9（0.6 - 1.2），喝茶者为0.8（0.6 - 1.2））。社会阶层、饮酒与结直肠癌之间的关系在性别和年龄分层中是一致的。本研究证实结直肠癌与社会阶层呈正相关。与饮酒的关联显然比先前报道的更强，这可能是由于偶然性作用和/或该阿根廷人群中饮酒的特殊相关因素所致。
