一系列1,2,4-三唑基杂羧酸衍生物的中枢神经系统作用
CNS effects of a series of 1,2,4-triazolyl heterocarboxylic derivatives.
作者信息
Darias V, Abdala S, Martin-Herrera D, Tello M L, Vega S
机构信息
Departamento de Farmacología, Facultad de Farmacia, Universidad de La Laguna, Tenerife, Spain.
出版信息
Pharmazie. 1998 Jul;53(7):477-81.
PMID:9699225
Abstract
A series of 1,2,4-triazolyl heterocarboxylic derivatives were tested for acute toxicity and CNS effects in mice. Several of these compounds demonstrated clear psychostimulant effects. Other components of the series, however, showed a definite central depressant activity. Some of the screened derivatives showed interesting anxiolytic properties.
摘要
对一系列1,2,4 - 三唑基杂环羧酸衍生物进行了小鼠急性毒性和中枢神经系统作用测试。其中几种化合物表现出明显的精神兴奋作用。然而，该系列中的其他成分则显示出明确的中枢抑制活性。一些经筛选的衍生物表现出有趣的抗焦虑特性。
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