Gribanov G A, Golovko M Iu
Tver State University.
Vopr Med Khim. 1998 May-Jun;44(3):241-7.
The influence of cytoprotecting concentrations of bovine serum albumin (BSA) on the autolytic alterations of rat brain white and grey matters in the physiological solution containing was investigated, In the autolysed grey matter exogenous BSA prevents the decomposition of phospholipids and the gaining the free fatty acids up to 1 hr of incubation and increased the content of cholesterol esters at the 4th and 24th hrs of autolysis BSA increased the phospholipids breakdown at the late stages of autolysis (24 hrs). On the contrary, BSA activated the phospholipids break down in the white matter already at the early periods of incubation (10 mins). It also altered the character of cholesterol and esters pendulous interactions on the opposite one, promoting the significant increase of the latters, especially at the 10th min and 4th hr of the autolysis.
研究了细胞保护浓度的牛血清白蛋白（BSA）对含有生理溶液的大鼠脑白质和灰质自溶改变的影响。在自溶的灰质中，外源性BSA可防止磷脂分解和游离脂肪酸的生成，直至孵育1小时，并在自溶的第4小时和第24小时增加胆固醇酯的含量。在自溶后期（24小时），BSA增加了磷脂的分解。相反，BSA在孵育早期（10分钟）就激活了白质中磷脂的分解。它还改变了胆固醇和酯类悬挂相互作用的性质，促进了后者的显著增加，尤其是在自溶的第10分钟和第4小时。
