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适用于疫苗用途的1期Q热抗原的制备。

Preparation of phase 1Q fever antigen suitable for vaccine use.

作者信息

Spicer D S, DeSanctis A N

出版信息

Appl Environ Microbiol. 1976 Jul;32(1):85-8. doi: 10.1128/aem.32.1.85-88.1976.

DOI:10.1128/aem.32.1.85-88.1976
PMID:970938
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC170010/
Abstract

Five lots of phase 1 Q fever antigen suitable for use as vaccine were prepared utilizing the Freon-brushite method of antigen purification. Antigen concentration levels were initially adjusted turbidimetrically and later confirmed by antibody response in guinea pigs. Data showed that all lots were essentially identical in purity and antigenicity.

摘要

利用氟利昂-透辉石抗原纯化方法制备了五批适合用作疫苗的1期Q热抗原。抗原浓度水平最初通过比浊法进行调整，随后通过豚鼠的抗体反应进行确认。数据表明，所有批次在纯度和抗原性方面基本相同。

相似文献

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Preparation of phase 1Q fever antigen suitable for vaccine use.适用于疫苗用途的1期Q热抗原的制备。
Appl Environ Microbiol. 1976 Jul;32(1):85-8. doi: 10.1128/aem.32.1.85-88.1976.
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引用本文的文献

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Low-dose priming before vaccination with the phase I chloroform-methanol residue vaccine against Q fever enhances humoral and cellular immune responses to Coxiella burnetii.在接种I期抗Q热氯仿-甲醇残留疫苗之前进行低剂量致敏可增强针对伯氏考克斯体的体液免疫和细胞免疫反应。
Clin Vaccine Immunol. 2008 Oct;15(10):1505-12. doi: 10.1128/CVI.00119-08. Epub 2008 Aug 13.
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J Bacteriol. 1988 Mar;170(3):1227-34. doi: 10.1128/jb.170.3.1227-1234.1988.
6
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Infect Immun. 1978 Nov;22(2):627-8. doi: 10.1128/iai.22.2.627-628.1978.
7
Cell-mediated immune responses of guinea pigs to an inactivated phase I Coxiella burnetii vaccine.豚鼠对灭活的Ⅰ期伯纳特柯克斯体疫苗的细胞介导免疫反应。
Infect Immun. 1978 Jan;19(1):194-8. doi: 10.1128/iai.19.1.194-198.1978.

本文引用的文献

1
METHOD FOR THE PRODUCTION OF A PURIFIED DRY Q FEVER VACCINE.纯化干Q热疫苗的生产方法。
J Bacteriol. 1961 May;81(5):794-9. doi: 10.1128/jb.81.5.794-799.1961.
2
Immunization against scrub typhus. II. Preparation of lyophilized living vaccine.恙虫病免疫。II. 冻干活疫苗的制备。
Am J Hyg. 1951 May;53(3):326-31. doi: 10.1093/oxfordjournals.aje.a119457.
3
Intradermal sensitivity testing in man with a purified vaccine for Q fever.用人用Q热纯化疫苗进行皮内敏感性试验。
Am J Public Health Nations Health. 1962 Jan;52(1):87-93. doi: 10.2105/ajph.52.1.87.
4
STAINING RICKETTSIAE IN YOLK-SAC CULTURES.卵黄囊培养物中里克次氏体的染色
Stain Technol. 1964 May;39:135-40. doi: 10.3109/10520296409061219.
5
THE INFLUENCE OF PHASE ON THE PROTECTIVE POTENCY OF Q FEVER VACCINE.阶段对Q热疫苗保护效力的影响。
J Immunol. 1964 Mar;92:404-12.
6
Phase variation of the Nine Mile and other strains of Rickettsia burneti.伯纳特立克次氏体九里株及其他菌株的相变
Can J Microbiol. 1956 May;2(3):310-21. doi: 10.1139/m56-036.
7
Preparation of highly purified concentrates of Coxiella burneti.伯氏考克斯氏体高纯度浓缩物的制备。
Proc Soc Exp Biol Med. 1970 Dec;135(3):706-8. doi: 10.3181/00379727-135-35125.
8
Purification of large quantities of coxiella burnetii rickettsia by density gradient zonal centrifugation.通过密度梯度区带离心法纯化大量伯纳特柯克斯体立克次氏体。
Appl Microbiol. 1972 May;23(5):1015-22. doi: 10.1128/am.23.5.1015-1022.1972.
9
Preparation of purified suspensions of Coxiella burneti by Genetron extraction followed by continuous-flow ultracentrifugation.通过Genetron萃取，随后进行连续流超速离心制备伯纳特柯克斯体的纯化悬浮液。
Appl Microbiol. 1972 May;23(5):841-5. doi: 10.1128/am.23.5.841-845.1972.
10
A microagglutination technique for detection and measurement of rickettsial antibodies.一种用于检测和测量立克次氏体抗体的微量凝集技术。
Acta Virol. 1969 Jan;13(1):60-6.