Weiss C, Welsch B, Albert M, Friedmann B, Strobel G, Jost J, Nawroth P, Bärtsch P
Department of Sports Medicine, University of Heidelberg, Germany.
Med Sci Sports Exerc. 1998 Aug;30(8):1205-10. doi: 10.1097/00005768-199808000-00004.
The present study was conducted to evaluate the role of the duration of exercise and the impact of the exercise type for exercise-induced activation of coagulation.
Eleven male triathletes were subjected to stepwise maximal (17 min) and 1-h maximal exercise in swimming, cycling, and running. Changes of hemostatic variable sand of plasma thrombomodulin, a marker of endothelial cell activation, were monitored.
Irrespective of the type of exercise, alterations in markers of thrombin (prothrombin fragment 1 + 2, thrombin-antithrombin III complexes) and fibrin formation (fibrinopeptide A) were more pronounced after 1-h exercise than after stepwise maximal exercise. Hemostatic parameters rose to the highest levels after running resulting in substantial fibrin formation as indicated by fibrinopeptide A increasing from 1.33 ng.mL-1 to 2.25 ng.mL (P < 0.05) after 1-h exercise testing. Significant changes of plasma thrombomodulin were detected exclusively after running with increases from 38.2 ng.mL-1 to 44.2 ng.mL-1 (1 h, P < 0.01).
The data demonstrated that prolonged exercise is necessary for exercise-induced activation of coagulation resulting in thrombin and fibrin formation and suggested that endothelial cell activation possibly due to mechanical factors associated with running might play a role.
本研究旨在评估运动持续时间以及运动类型对运动诱导的凝血激活的作用。
11名男性铁人三项运动员分别进行了游泳、骑自行车和跑步的逐步最大强度（17分钟）和1小时最大强度运动。监测止血变量以及内皮细胞激活标志物血浆血栓调节蛋白的变化。
无论运动类型如何，1小时运动后凝血酶标志物（凝血酶原片段1 + 2、凝血酶 - 抗凝血酶III复合物）和纤维蛋白形成标志物（纤维蛋白肽A）的变化比逐步最大强度运动后更明显。跑步后止血参数升至最高水平，导致大量纤维蛋白形成，1小时运动测试后纤维蛋白肽A从1.33 ng/mL增加到2.25 ng/mL表明了这一点（P < 0.05）。仅在跑步后检测到血浆血栓调节蛋白有显著变化，从38.2 ng/mL增加到44.2 ng/mL（1小时，P < 0.01）。
数据表明，长时间运动对于运动诱导的凝血激活并导致凝血酶和纤维蛋白形成是必要的，并且表明可能由于与跑步相关的机械因素导致的内皮细胞激活可能起作用。
