Ronin C
Laboratoire de Neurobiologie, Centre National de la Recherche Scientifique, Marseille, France.
Clin Chem Lab Med. 1998 Jun;36(6):373-8. doi: 10.1515/CCLM.1998.063.
Glycosylation is the most extensive of all post-translational modifications in proteins. It has important functions in their secretion, antigenicity and metabolic clearance through structural polymorphism. In recent years, advances in recombinant DNA technology allowed the production of recombinant therapeutic proteins, among which glycosylated proteins displayed differences compared to their native counterparts, including antigenic carbohydrates. In this review, we discuss the potential use of cloned glycosyltransferases in remodeling recombinant glycoprotein antigens as well as in synthesizing tumor-associated carbohydrate antigens.
糖基化是蛋白质所有翻译后修饰中最为广泛的一种。它通过结构多态性在蛋白质的分泌、抗原性和代谢清除方面具有重要功能。近年来，重组DNA技术的进展使得重组治疗性蛋白质得以生产，其中糖基化蛋白质与其天然对应物相比存在差异，包括抗原性碳水化合物。在本综述中，我们讨论了克隆的糖基转移酶在重塑重组糖蛋白抗原以及合成肿瘤相关碳水化合物抗原方面的潜在用途。
