Cornelis G R
Microbial Pathogenesis Unit, International Institute of Cellular and Molecular Pathology, Brussels, Belgium.
Folia Microbiol (Praha). 1998;43(3):253-61. doi: 10.1007/BF02818610.
The Yop virulon enables yersinias (Yersinia pestis, Y. pseudotuberculosis and Y. enterocolitica) to survive and multiply in the lymphoid tissues of their host. It is an integrated system allowing extracellular bacteria to communicate with the host cell's cytosol by injection of effector proteins. It is composed of four elements: (1) a contact or type III secretion system called Ysc, devoted to the secretion of Yop proteins. This secretion apparatus, made of some 22 proteins, recognizes the Yops by a short N-terminal signal that is not cleaved off during secretion; (2) a system designed to deliver bacterial proteins into eukaryotic target cells. This system is made of YopB, YopD and LcrV; (3) a control element (YopN) and (4) a set of effector Yop proteins designed to disarm these cells or disrupt their communications (YopE, YopH, YopM, YpkA/YopO, YopP). The whole virulon is encoded by a 70-kb plasmid called pYV. Transcription of the genes is controlled both by temperature and by contact with a eukaryotic cell.
Yop毒力蛋白分泌系统使耶尔森氏菌（鼠疫耶尔森氏菌、假结核耶尔森氏菌和小肠结肠炎耶尔森氏菌）能够在宿主的淋巴组织中存活和繁殖。它是一个完整的系统，可使胞外细菌通过注射效应蛋白与宿主细胞的胞质溶胶进行通信。它由四个部分组成：（1）一种称为Ysc的接触或III型分泌系统，专门用于分泌Yop蛋白。这种由约22种蛋白质组成的分泌装置通过一个短的N端信号识别Yop蛋白，该信号在分泌过程中不会被切除；（2）一个旨在将细菌蛋白递送至真核靶细胞的系统。该系统由YopB、YopD和LcrV组成；（3）一个控制元件（YopN）和（4）一组效应Yop蛋白，旨在使这些细胞失活或破坏其通信（YopE、YopH、YopM、YpkA/YopO、YopP）。整个毒力蛋白分泌系统由一个名为pYV的70 kb质粒编码。这些基因的转录受温度和与真核细胞接触的控制。
