菊科植物花中的三萜醇及其抗炎作用。

Triterpene alcohols from the flowers of compositae and their anti-inflammatory effects.

作者信息

Akihisa T, Yasukawa K, Oinuma H, Kasahara Y, Yamanouchi S, Takido M, Kumaki K, Tamura T

机构信息

College of Science and Technology, Nihon University, Tokyo, Japan.

出版信息

Phytochemistry. 1996 Dec;43(6):1255-60. doi: 10.1016/s0031-9422(96)00343-3.

DOI:10.1016/s0031-9422(96)00343-3

PMID:8987908

Abstract

Eleven tabular and nine ligulate flowers from 15 species of Compositae plants were investigated for their triterpene alcohol constituents. This led to the isolation and identification of 11 triterpene alcohols as follows: heliaol, taraxasterol, psi-taraxasterol, alpha-amyrin, beta-amyrin, lupeol, taraxerol, cycloartenol, 24-methyl-enecycloartanol, tirucalla-7,24-dienol and dammaradienol. The tabular flowers of Calendula officinalis, Carthamus tinctorius, Cosmos bipinnatus, Chrysanthemum morifolium, Helianthus annuus and Matricaria matricarioides showed a characteristic feature by containing helianol as the most predominant component (29-86%) in the triterpene alcohol fractions. The triterpene alcohols from Compositae flowers were evaluated with respect to their anti-inflammatory activity against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation (1 microgram per ear) in mice. All of these showed marked inhibitory activity, and their 50% inhibitory dose was 0.1-0.8 mg per ear.

摘要

对菊科15种植物的11朵管状花和9朵舌状花的三萜醇成分进行了研究。由此分离并鉴定出11种三萜醇，如下所示：海棉甾醇、蒲公英甾醇、假蒲公英甾醇、α-香树脂醇、β-香树脂醇、羽扇豆醇、蒲公英赛醇、环阿屯醇、24-亚甲基环阿屯醇、铁海棠-7,24-二烯醇和达玛二烯醇。金盏花、红花、大波斯菊、菊花、向日葵和母菊的管状花表现出一个特征，即三萜醇部分中以海棉甾醇作为最主要成分（29%-86%）。对菊科花朵中的三萜醇针对小鼠耳缘注射12-O-十四酰佛波醇-13-乙酸酯（每耳1微克）诱导的炎症的抗炎活性进行了评估。所有这些三萜醇均表现出显著的抑制活性，其50%抑制剂量为每耳0.1-0.8毫克。