Ono K, Maeshima K
Department of Anesthesia, Fukuyama Municipal Hospital.
Masui. 1998 Jul;47(7):848-51.
Sixty adult patients were assigned to one of 3 groups according to the anesthetic technique chosen: isolfurane inhalation, propofol infusion at a higher rate, and propofol infusion at a lower rate supplemented with epidural anesthesia. When the patients regained consciousness and orientation after surgery, they were shown a digit and asked to confirm it verbally. Memory of the digit was tested on the following day. The percentages of the patients who were able to recall the digit were significantly different among the 3 groups, 5%, 40% and 80%, respectively. We concluded that the amnesic effect of propofol was weaker than that of isoflurane when compared immediately after anesthesia. This tendency was more conspicuous when the dose of propofol was less with epidural anesthesia.
60名成年患者根据所选麻醉技术被分为3组之一：异氟烷吸入麻醉、较高速率丙泊酚输注以及较低速率丙泊酚输注并辅以硬膜外麻醉。术后患者恢复意识和定向力后，向他们展示一个数字并要求他们口头确认。次日测试对该数字的记忆。能够回忆起该数字的患者百分比在3组之间有显著差异，分别为5%、40%和80%。我们得出结论，麻醉后立即比较时，丙泊酚的遗忘作用弱于异氟烷。当丙泊酚剂量较小并辅以硬膜外麻醉时，这种趋势更为明显。
