Dan N, Safran S A
Department of Chemical Engineering, University of Delaware, Newark 19716, USA.
Biophys J. 1998 Sep;75(3):1410-4. doi: 10.1016/S0006-3495(98)74059-7.
The activity of embedded proteins is known to vary with lipid characteristics. Indeed, it has been shown that some cell-membrane proteins cannot function unless certain non-bilayer-forming lipids (i.e., nonzero spontaneous curvature) are present. In this paper we show that membranes exert a line tension on transmembrane proteins. The line tension, on the order of 1-100 kT/protein, varies with the lipid properties and the protein configuration. Thus, membranes composed of different lipids favor different protein conformations. Model predictions are in excellent agreement with the data of Keller et al. (Biophys. J. 1993, 65:23-27) regarding the conductance of alamethicin channels.
已知嵌入蛋白质的活性会随脂质特性而变化。事实上，已经表明某些细胞膜蛋白只有在存在某些非双层形成脂质（即非零自发曲率）时才能发挥功能。在本文中，我们表明膜会对跨膜蛋白施加线张力。线张力的量级为1 - 100 kT/蛋白，它会随脂质性质和蛋白质构象而变化。因此，由不同脂质组成的膜有利于不同的蛋白质构象。模型预测与凯勒等人（《生物物理杂志》，1993年，65卷：23 - 27页）关于短杆菌肽通道电导的数据高度吻合。
