Abe S, Tansho S, Ishibashi H, Inagaki N, Komatsu Y, Yamaguchi H
Department of Microbiology and Immunology, Teikyo University School of Medicine, Itabashi, Tokyo.
Immunopharmacol Immunotoxicol. 1998 Aug;20(3):421-31. doi: 10.3109/08923979809034824.
Protective effects of a kampo medicine, Juzen-taiho-to (TJ-48) and its herbal components against experimental candidiasis in cyclophosphamide-induced immunosuppressive mice were investigated. ICR mice were immunosuppressed by intraperitoneal treatment with cyclophosphamide (day-4) and were orally given TJ-48 or one of its 10 herbal components for 4 consecutive days (day-4--1). They were then challenged intravenously with a lethal dose of Candida albicans (day 0). An oral dose of 1 g/kg/day of TJ-48 prolonged their life span. A similar protective effect was obtained by treatment with its component drugs Ginseng radix, Glycyrrhizae radix, Atractylodis lancea rhizoma or Cnidii rhizoma. These herbal components were suggested to have a main role in the protective effect of Juzen-taiho-to against Candida infection.
研究了汉方药物十全大补汤（TJ - 48）及其草药成分对环磷酰胺诱导的免疫抑制小鼠实验性念珠菌病的保护作用。ICR小鼠通过腹腔注射环磷酰胺（第4天）进行免疫抑制，并连续4天（第4 - 1天）口服TJ - 48或其10种草药成分之一。然后静脉注射致死剂量的白色念珠菌对其进行攻击（第0天）。口服剂量为1 g/kg/天的TJ - 48可延长其寿命。用其成分药物人参、甘草、苍术或细辛进行治疗也获得了类似的保护作用。这些草药成分被认为在十全大补汤对念珠菌感染的保护作用中起主要作用。
