Shimomura T, Mori E, Hirono N, Imamura T, Yamashita H
Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan.
Arch Neurol. 1998 Sep;55(9):1242-5. doi: 10.1001/archneur.55.9.1242.
Surgical exclusion of portions of the gastrointestinal tract is a predisposing risk factor for the development of Wernicke-Korsakoff syndrome. When this disease occurs, it is usually within weeks after the gastrointestinal surgery. However, it is not well known that Wernicke-Korsakoff syndrome may occur after a long latent interval following gastrectomy.
A research-oriented hospital.
Three patients without a history of alcoholism or dietary deprivation developed Wernicke-Korsakoff syndrome 2 to 20 years after undergoing gastrectomy. In these patients, minor changes in dietary habit led to the development of Wernicke-Korsakoff syndrome.
In addition to a long-standing latent deficiency in thiamin levels due to defective absorption following gastrectomy or gastrojejunostomy, other minor factors that may influence the intake of thiamin and the need for thiamin in subjects who have undergone gastrectomy may cause a state of thiamin deficiency resulting in Wernicke-Korsakoff syndrome. Results from our study indicate that the following measures are mandatory: educating patients about proper dietary habits, carefully monitoring their thiamin intake, recognizing Wernicke-Korsakoff syndrome early, and treating it immediately with appropriate measures.
胃肠道部分的手术切除是韦尼克 - 科尔萨科夫综合征发生的一个诱发危险因素。当这种疾病发生时，通常是在胃肠道手术后数周内。然而，胃切除术后经过很长的潜伏期可能发生韦尼克 - 科尔萨科夫综合征这一点并不广为人知。
一家以研究为导向的医院。
三名无酗酒或饮食缺乏病史的患者在接受胃切除术后2至20年发生了韦尼克 - 科尔萨科夫综合征。在这些患者中，饮食习惯的微小变化导致了韦尼克 - 科尔萨科夫综合征的发生。
除了由于胃切除或胃空肠吻合术后吸收不良导致的长期潜在硫胺素水平缺乏外，其他可能影响硫胺素摄入以及胃切除术后患者对硫胺素需求的微小因素，可能会导致硫胺素缺乏状态，从而引发韦尼克 - 科尔萨科夫综合征。我们的研究结果表明，必须采取以下措施：对患者进行适当饮食习惯的教育，仔细监测他们的硫胺素摄入量，早期识别韦尼克 - 科尔萨科夫综合征，并立即采取适当措施进行治疗。
