Single S, Borst A
Friedrich-Miescher-Laboratory of the Max-Planck-Society, Spemannstrasse 37-39, D-72076 Tuebingen, Germany.
Science. 1998 Sep 18;281(5384):1848-50. doi: 10.1126/science.281.5384.1848.
The mechanisms underlying visual motion detection can be studied simultaneously in different cell compartments in vivo by using calcium as a reporter of the spatiotemporal activity distribution in single motion-sensitive cells of the fly. As predicted by the Reichardt model, local dendritic calcium signals are found to indicate the direction and velocity of pattern motion but are corrupted by spatial pattern properties. The latter are canceled out by spatial integration, thus leading to a purely directional selective output signal in the axon. These findings attribute a specific computational task to the dendrites of visual interneurons and imply a functional interpretation of dendritic morphology.
通过使用钙作为果蝇单个运动敏感细胞中时空活动分布的报告分子，可以在体内不同细胞区室中同时研究视觉运动检测的潜在机制。正如赖夏德模型所预测的那样，局部树突状钙信号被发现可指示模式运动的方向和速度，但会受到空间模式特性的影响。后者通过空间整合被抵消，从而在轴突中产生一个纯方向选择性输出信号。这些发现将特定的计算任务归因于视觉中间神经元的树突，并暗示了树突形态的功能解释。
