Das Samarjit, Santani Dev D, Dhalla Naranjan S
Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
Exp Clin Cardiol. 2007 Spring;12(1):5-10.
Both epidemiological and experimental studies have revealed that intake of wine, particularly red wine, in moderation protects cardiovascular health; however, the experimental basis for such an action is not fully understood. Because all types of red wine contain varying amounts of alcohol and antioxidants, it is likely that the cardioprotective effect of red wine is due to both these constituents. In view of its direct action on the vascular smooth muscle cells, alcohol may produce coronary vasodilation in addition to attenuating oxidative stress by its action on the central nervous system. The antioxidant components of red wine may provide cardioprotection by their ability to reduce oxidative stress in the heart under different pathological conditions. Mild-to-moderate red wine consumption improves cardiac function in the ischemic myocardium through the protection of endothelial function, the expression of several cardioprotective oxidative stress-inducible proteins, as well as the activation of adenosine receptors and nitrous oxide synthase mechanisms.
流行病学和实验研究均表明，适量饮用葡萄酒，尤其是红酒，对心血管健康具有保护作用；然而，这种作用的实验依据尚未完全明确。由于所有类型的红酒都含有不同量的酒精和抗氧化剂，红酒的心脏保护作用可能归因于这两种成分。鉴于酒精对血管平滑肌细胞的直接作用，它除了通过对中枢神经系统的作用减轻氧化应激外，还可能导致冠状动脉血管舒张。红酒中的抗氧化成分可能通过在不同病理条件下降低心脏氧化应激的能力来提供心脏保护。轻度至中度饮用红酒可通过保护内皮功能、几种心脏保护氧化应激诱导蛋白的表达以及腺苷受体和一氧化氮合酶机制的激活来改善缺血心肌的心脏功能。
