β-内酰胺酶：实时的蛋白质进化

beta-Lactamases: protein evolution in real time.

作者信息

Petrosino J, Cantu C, Palzkill T

机构信息

Dept of Microbiology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.

出版信息

Trends Microbiol. 1998 Aug;6(8):323-7. doi: 10.1016/s0966-842x(98)01317-1.

DOI:10.1016/s0966-842x(98)01317-1

PMID:9746943

Abstract

The evolution and spread of bacteria resistant to beta-lactam antibiotics has progressed at an alarming rate. Bacteria may acquire resistance to a given drug by mutation of pre-existing genes or by the acquisition of new genes from other bacteria. One ongoing example of these mechanisms is the evolution of new variants of the TEM and SHV beta-lactamases with altered substrate specificity.

摘要

对β-内酰胺类抗生素耐药的细菌的演变与传播速度惊人。细菌可通过既有基因的突变或从其他细菌获取新基因而获得对某种特定药物的耐药性。这些机制的一个正在发生的例子是具有改变的底物特异性的TEM和SHVβ-内酰胺酶新变体的演变。