Tsukazaki N, Watanabe M, Irifune H
Department of Dermatology, Nagasaski University, School of Medicine, Japan.
Br J Dermatol. 1998 Jun;138(6):1015-7. doi: 10.1046/j.1365-2133.1998.02269.x.
We studied the prevalence of hepatitis C virus (HCV) infection in 20 Japanese patients with sporadic-type porphyria cutanea tarda (PCT). Seventeen of the 20 patients (85%) had anti-HCV antibodies. Biochemical remission was observed in nine patients, six of whom still had positive HCV RNA copies. These results suggest that HCV infection is a triggering factor for PCT in Japan. However, continuous HCV infection seems to exert little influence on the maintenance of abnormal porphyrin metabolism. Hepatocellular carcinoma (HCC) developed in five of the 17 HCV-positive patients, three of whose PCT was in remission. Four of these patients showed chronic active hepatitis or cirrhosis on liver biopsy. PCT patients with HCV infection should be followed up long-term because of the possibility of HCC. To evaluate the risk of HCC, liver biopsy may be required, even when the patient is in biochemical remission.
我们研究了20例散发性迟发性皮肤卟啉症（PCT）日本患者的丙型肝炎病毒（HCV）感染率。20例患者中有17例（85%）抗HCV抗体呈阳性。9例患者实现了生化缓解，其中6例HCV RNA拷贝仍为阳性。这些结果表明，在日本，HCV感染是PCT的触发因素。然而，持续的HCV感染似乎对异常卟啉代谢的维持影响不大。17例HCV阳性患者中有5例发生了肝细胞癌（HCC），其中3例的PCT处于缓解期。这些患者中有4例肝活检显示为慢性活动性肝炎或肝硬化。由于存在发生HCC的可能性，HCV感染的PCT患者应长期随访。为评估HCC风险，即使患者处于生化缓解期，也可能需要进行肝活检。
