Rodríguez-Morán M, Guerrero-Romero F, Lazcano-Burciaga G
Mexican Social Security Institute and Research Group on Diabetes and Chronic Illnesses, Durango.
J Diabetes Complications. 1998 Sep-Oct;12(5):273-8. doi: 10.1016/s1056-8727(98)00003-8.
The beneficial effect of dietary fiber in the management of type II diabetes is still controversial and has not been totally demonstrated. The purpose of this study was to determine the plasma-lowering effects of 5 g t.i.d. of Plantago Psyllium, as an adjunct to dietary therapy, on lipid and glucose levels, in patients with type II diabetes. Patients were randomly selected from an outpatient clinic of primary care to participate in a double-blind placebo-controlled study in which Plantago Psyllium or placebo was given in combination with a low fat diet. One hundred twenty-five subjects were included in the study that consisted in a 6-week period of diet counseling followed by a 6-week treatment period. Fasting plasma glucose, total plasma cholesterol, LDL cholesterol, HDL cholesterol and triglyceride levels were measured every 2 weeks. The test products (Psyllium or placebo) were supplied to subjects in identically labeled foil packets containing a 5-g dose of product, to consume three doses per day (of 5 g each one), before regular meals. There was an excellent tolerance to Psyllium, without significant adverse effects. No significant changes were observed in the patient's weight for both groups (not significant). Fasting plasma glucose, total cholesterol, LDL cholesterol, and triglycerides levels, showed a significant reduction (p < 0.05), whereas HDL cholesterol increased significantly (p < 0.01) following Psyllium treatment. Our results show that 5 g t.i.d. of Psyllium is useful, as an adjunct to dietary therapy, in patients with type II diabetes, to reduce plasma lipid and glucose levels, resolving the compliance conflict associated with the ingest of a great amount of fiber in customary diet.
膳食纤维在II型糖尿病管理中的有益作用仍存在争议，尚未得到充分证实。本研究的目的是确定每日三次服用5克车前草籽壳作为饮食疗法的辅助手段，对II型糖尿病患者血脂和血糖水平的降低作用。患者从初级保健门诊随机选取，参与一项双盲安慰剂对照研究，其中车前草籽壳或安慰剂与低脂饮食联合使用。125名受试者纳入该研究，包括为期6周的饮食咨询期，随后是6周的治疗期。每2周测量空腹血糖、总血浆胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯水平。测试产品（车前草籽壳或安慰剂）以相同标签的铝箔包装提供给受试者，每包含有5克产品，每天在正餐前服用三剂（每剂5克）。对车前草籽壳耐受性良好，无明显不良反应。两组患者体重均无显著变化（无统计学意义）。服用车前草籽壳治疗后，空腹血糖、总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平显著降低（p<0.05），而高密度脂蛋白胆固醇显著升高（p<0.01）。我们的结果表明，每日三次服用5克车前草籽壳作为饮食疗法的辅助手段，对II型糖尿病患者降低血脂和血糖水平是有效的，解决了常规饮食中摄入大量纤维带来的依从性问题。
