Gelissen I C, Brodie B, Eastwood M A
Gastro-Intestinal Laboratory, Western General Hospital, Edinburg, UK.
Am J Clin Nutr. 1994 Feb;59(2):395-400. doi: 10.1093/ajcn/59.2.395.
The diet of six normal and five ileostomy subjects was supplemented with 10 g/d Plantago ovata psyllium husk for 3 wk while six normal and four ileostomy subjects received 10 g/d psyllium seed. Fecal and ileostomy output, sterol excretion, serum cholesterol, and triglycerides were measured before and after supplementation. The husk had no effect on cholesterol or triglyceride concentrations in either normal or ileostomy subjects. Total and high-density-lipoprotein-cholesterol concentrations were reduced on average by 6.4% and 9.3%, respectively, in the normal group after seed supplementation. No effect on fecal bile acid excretion in the normal subjects was found after both regimes. Ileostomy bile acids were increased (on average 25%) after seed supplementation, whereas no effect on cholesterol concentrations was found. These results suggest that psyllium seed might be more effective than the husk in reducing serum cholesterol, that this cholesterol-lowering effect is not mediated by increased fecal bile acid losses, and increased ileal losses of bile acids might be compensated for by enhanced reabsorption in the colon.
给6名正常受试者和5名回肠造口术患者的饮食中每日补充10克卵叶车前草籽壳，持续3周，同时给6名正常受试者和4名回肠造口术患者每日补充10克车前草籽。在补充前后分别测量粪便和回肠造口排出物、固醇排泄、血清胆固醇和甘油三酯。壳对正常受试者或回肠造口术患者的胆固醇或甘油三酯浓度均无影响。补充籽后，正常组的总胆固醇和高密度脂蛋白胆固醇浓度平均分别降低了6.4%和9.3%。两种方案后均未发现对正常受试者粪便胆汁酸排泄有影响。补充籽后回肠造口胆汁酸增加（平均增加25%），而对胆固醇浓度无影响。这些结果表明，车前草籽在降低血清胆固醇方面可能比籽壳更有效，这种降胆固醇作用不是由粪便胆汁酸损失增加介导的，回肠胆汁酸损失增加可能通过结肠中增强的重吸收得到补偿。
