可乐定对胃肠转运时间的影响。
Effect of clonidine on gastrointestinal transit time.
作者信息
Mann N S, Shinkle J M
机构信息
Texas A&M University, College of Medicine, VA Medical Center, Temple 76504, USA.
出版信息
Hepatogastroenterology. 1998 Jul-Aug;45(22):1023-5.
BACKGROUND/AIMS: Orocecal time can be measured by lactulose H2 breath test. Duodenal entry time can be evaluated by measuring D-xylose; the duodeno-cecal time can be derived by subtracting duodenal entry time from orocecal time. In this study we established the normal value of these parameters for our laboratory in males and also evaluated the effect of clonidine on these parameters.
METHODOLOGY
In 9 healthy male volunteers orocecal time was measured by the lactulose H2 breath test. Duodenal entry time was established by measuring blood D-xylose. Duodenocecal time was derived by subtracting duodenal entry time from orocecal time.
RESULTS
The mean orocecal time was 54.44 + 3.77 minutes; the mean duodenal entry time was 17.22 + 3.15 minutes and the mean duodenocecal time was 37.22 + 3.16 minutes.
CONCLUSIONS
Oral clonidine prolonged orocecal, duodenal entry and duodenocecal times in only 33% of the subjects.
背景/目的：口盲肠时间可通过乳果糖氢气呼气试验来测量。十二指肠通过时间可通过测量D-木糖来评估；十二指肠-盲肠时间可通过口盲肠时间减去十二指肠通过时间得出。在本研究中，我们确定了本实验室男性这些参数的正常值，并评估了可乐定对这些参数的影响。
方法
对9名健康男性志愿者进行乳果糖氢气呼气试验以测量口盲肠时间。通过测量血液中的D-木糖确定十二指肠通过时间。十二指肠-盲肠时间通过口盲肠时间减去十二指肠通过时间得出。
结果
平均口盲肠时间为54.44 + 3.77分钟；平均十二指肠通过时间为17.22 + 3.15分钟，平均十二指肠-盲肠时间为37.22 + 3.16分钟。
结论
口服可乐定仅使33%的受试者的口盲肠、十二指肠通过及十二指肠-盲肠时间延长。
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