来自海绵绿肉盘海绵的新型二酮哌嗪。

New diketopiperazines from the sponge Dysidea chlorea.

作者信息

Fu X, Ferreira M L, Schmitz F J, Kelly-Borges M

机构信息

Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, Zealand, USA.

出版信息

J Nat Prod. 1998 Oct;61(10):1226-31. doi: 10.1021/np980123l.

DOI:10.1021/np980123l

PMID:9784157

Abstract

Twelve new polychlorinated diketopiperazines (7-18), along with six known ones (1-6) and a known sterol (19), were isolated from the sponge Dysidea chlorea, collected from Yap, Federated States of Micronesia. The structures of dysamides I-T (7-18) were elucidated by spectroscopic methods, and one (8) was confirmed by chemical conversion. The stereochemistry of the dysamides is discussed.

摘要

从密克罗尼西亚联邦雅浦岛采集的绿指海绵（Dysidea chlorea）中分离出12种新的多氯代二酮哌嗪（7 - 18）、6种已知化合物（1 - 6）和1种已知甾醇（19）。通过光谱方法阐明了dysamides I - T（7 - 18）的结构，其中一种（8）通过化学转化得以确证。并对dysamides的立体化学进行了讨论。