人细小病毒B19：无偿献血者中病毒DNA的流行情况及输血受者的临床结局
Human parvovirus B19: prevalence of viral DNA in volunteer blood donors and clinical outcomes of transfusion recipients.
作者信息
Jordan J, Tiangco B, Kiss J, Koch W
机构信息
Department of Pathology, Magee-Women's Research Institute, University of Pittsburgh, PA 15213, USA. jordanja+@pitt.edu
出版信息
Vox Sang. 1998;75(2):97-102.
BACKGROUND AND OBJECTIVES
Blood donor units are not screened for human parvovirus B19 (B19) even though it can be acquired via blood products. We estimated the prevalence of B19 in a US volunteer blood donor population and determined the clinical outcomes of transfusion recipients.
MATERIALS AND METHODS
Donor units were screened for B19 DNA by PCR, and positive units analyzed by EIA for B19 Ig. Unit usage was determined and recipient chart review conducted.
RESULTS
B19 DNA was detected in 11/9, 568 allogeneic units (0.1%), of which 3 had no measurable B19 Ig. One individual developed anemia consistent with B19 infection after receiving a DNA+ unit lacking B19 Ig.
CONCLUSIONS
The apparent low incidence of disease in patients transfused with B19 DNA+ components may be due to coexistence of neutralizing antibodies in donors and/or recipients.
背景与目的
尽管人类细小病毒B19（B19）可通过血液制品传播，但献血单位并未对其进行筛查。我们估计了美国志愿献血人群中B19的流行率，并确定了输血受者的临床结局。
材料与方法
通过聚合酶链反应（PCR）对献血单位进行B19 DNA筛查，对阳性单位采用酶免疫分析（EIA）检测B19 Ig。确定单位使用情况并查阅受者病历。
结果
在9568份异体献血单位中，检测到11份B19 DNA阳性（0.1%），其中3份未检测到可测量的B19 Ig。1名个体在接受了一份缺乏B19 Ig的DNA阳性单位血液后，出现了与B19感染相符的贫血症状。
结论
输注B19 DNA阳性成分的患者中疾病发生率明显较低，可能是由于供者和/或受者体内存在中和抗体。
Zotero 插件