Hench L L
Department of Materials, Imperial College of Science, Technology and Medicine, London, UK.
Biomaterials. 1998 Aug;19(16):1419-23. doi: 10.1016/s0142-9612(98)00133-1.
The survivability half-life of prostheses made with current bio-inert materials is approximately 15 years, depending upon clinical applications. Bioactive materials improve device lifetime but have mechanical limitations. This paper proposes that biomaterials research needs to focus on regeneration of tissues instead of replacement. Alternatives are: use hierarchical bioactive scaffolds to engineer in vitro living cellular constructs for transplantation, or use resorbable bioactive particulates or porous networks to activate in vivo the mechanisms of tissue regeneration.
目前使用生物惰性材料制成的假体的存活半衰期约为15年，这取决于临床应用情况。生物活性材料可延长器械使用寿命，但存在机械性能方面的限制。本文提出生物材料研究应专注于组织再生而非替代。替代方法有：使用分级生物活性支架在体外构建有生命的细胞结构体用于移植，或使用可吸收的生物活性微粒或多孔网络在体内激活组织再生机制。
