Kwon Jiyoung, Kim Hyun-Jung
Department of Conservative Dentistry, Kyung Hee University Dental Hospital, Seoul 02453, Republic of Korea.
Department of Conservative Dentistry, School of Dentistry, Kyung Hee University, Seoul 02453, Republic of Korea.
J Funct Biomater. 2025 May 19;16(5):188. doi: 10.3390/jfb16050188.
Conventional calcium silicate cement (CSC) formulations often exhibit insufficient mechanical strength and low initial stability. This study aimed to develop an organic-inorganic hybrid biomaterial by incorporating an elastin-like polypeptide (ELP) (V125E8) and bioactive glass (BG) (63S) into CSC to improve its mechanical properties and wash-out resistance during the initial setting. Experimental groups included ProRoot MTA (Dentsply Sirona, USA) as a control (0BG), inorganic hybrids containing BG (2% or 5%; 2BG, 5BG), and organic-inorganic hybrids combining BG (2% or 5%; 2BG-L, 5BG-L) with a 10 wt% ELP solution. The compressive strength, microhardness, and wash-out resistance of the specimens were evaluated. The organic-inorganic hybrid groups (2BG-L and 5BG-L) exhibited significantly higher compressive strength and microhardness than the control (0BG) and inorganic-only groups (2BG and 5BG). Additionally, the incorporation of ELP markedly improved wash-out resistance, minimizing material disintegration during the initial setting in aqueous environments. The organic-inorganic hybrid groups (2BG-L and 5BG-L) exhibited significantly higher compressive strength and microhardness than the control (0BG) and inorganic-only groups (2BG and 5BG). Additionally, the incorporation of ELP markedly improved wash-out resistance, minimizing material disintegration during the initial setting in aqueous environments.
传统的硅酸钙水泥（CSC）配方通常表现出机械强度不足和初始稳定性低的问题。本研究旨在通过将类弹性蛋白多肽（ELP）（V125E8）和生物活性玻璃（BG）（63S）掺入CSC中，开发一种有机-无机杂化生物材料，以改善其机械性能和初始凝固期间的耐冲刷性。实验组包括作为对照的ProRoot MTA（美国登士柏西诺德公司）（0BG）、含BG的无机杂化物（2%或5%；2BG、5BG）以及将BG（2%或5%；2BG-L、5BG-L）与10 wt% ELP溶液混合的有机-无机杂化物。对试样的抗压强度、显微硬度和耐冲刷性进行了评估。有机-无机杂化组（2BG-L和5BG-L）的抗压强度和显微硬度显著高于对照组（0BG）和仅含无机成分的组（2BG和5BG）。此外，ELP的掺入显著提高了耐冲刷性，最大限度地减少了在水环境中初始凝固期间的材料崩解。有机-无机杂化组（2BG-L和5BG-L）的抗压强度和显微硬度显著高于对照组（0BG）和仅含无机成分的组（2BG和5BG）。此外，ELP的掺入显著提高了耐冲刷性，最大限度地减少了在水环境中初始凝固期间的材料崩解。
