Ordaz V A, Castaneda C B, Campos C L, Rodríguez V M, Saenz J G, Ríos P C
Unidad de Investigación en Epidemiología Clínica, Hospital de, IMSS Torreón, Coahuila.
Rev Alerg Mex. 1998 Jul-Aug;45(4):106-11.
In order to determine the correlation between the concentration of environmental pollen and the frequency of asthmatic exacerbations in La Comarca Lagunera (México), a study in a cohort of a 104 diagnosed patients suffering allergic asthma was carried out monitoring monthly from July '93 to July '95 in order to register the existence of asthmatic exacerbations. Environmental samples were taken weekly during the same period of time through a PST high volume collector (Andersen Samplers Inc). The above mentioned samples were processed under acetolysis technics and the pollen grain count under light microscopy. Linear correlation measures were made between the rates of asthmatic exacerbations and the concentration of pollen grain in m3 of air by means of a statistical computer program SAS. There was a 1469 persons/month follow up ('X 15.5) and the correlation between the rates of asthmatic exacerbations and the concentration of environmental pollen was relevant (r = 0.63, r2 = 0.39, p < 0.01). The correlation increased (r = 0.70, r2 = 0.49 and p < 0.01) when the asthmatic exacerbations associated to infectious disease in the upper respiratory system were restricted. The conclusion reached is that the concentration of environment pollen has influence in the development of asthmatic exacerbations in patients with allergic asthma.
为了确定墨西哥拉科马卡-拉古内拉地区环境花粉浓度与哮喘急性加重频率之间的相关性，对104名确诊为过敏性哮喘的患者进行了一项队列研究，从1993年7月至1995年7月每月进行监测，以记录哮喘急性加重的情况。在同一时期，每周通过PST大容量收集器（安德森采样器公司）采集环境样本。上述样本采用乙酰解技术处理，并在光学显微镜下进行花粉粒计数。借助统计计算机程序SAS，对哮喘急性加重率与每立方米空气中花粉粒浓度之间进行线性相关测量。随访时间为1469人/月（平均15.5个月），哮喘急性加重率与环境花粉浓度之间的相关性显著（r = 0.63，r2 = 0.39，p < 0.01）。当排除与上呼吸道感染相关的哮喘急性加重情况后，相关性增强（r = 0.70，r2 = 0.49，p < 0.01）。得出的结论是，环境花粉浓度对过敏性哮喘患者哮喘急性加重的发生有影响。
