Hakim R B, Gray R H, Zacur H
Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Fertil Steril. 1998 Oct;70(4):632-7. doi: 10.1016/s0015-0282(98)00257-x.
To examine the effects of alcohol and caffeine on conception.
Prospective observational study.
Healthy volunteers in two manufacturing facilities.
PATIENT(S): One hundred twenty-four women who provided daily urine samples for measurement of steroid hormones and hCG, and prospective information about alcohol and caffeine consumption.
MAIN OUTCOME MEASURE(S): Probability of conception per 100 menstrual cycles.
RESULT(S): There was >50% reduction in the probability of conception during a menstrual cycle during which participants consumed alcohol. Caffeine consumption did not independently affect the probability of conception but may enhance alcohol's negative effect. Women who abstained from alcohol and consumed less than one cup of coffee or its equivalent per day conceived 26.9 pregnancies per 100 menstrual cycles compared with 10.5 per 100 menstrual cycles among those who consumed any alcohol and more than one cup of coffee per day.
This study revealed an independent dose-related negative effect of alcohol consumption on the ability to conceive. Our results suggest that women who are attempting to conceive should abstain from consuming alcohol.
研究酒精和咖啡因对受孕的影响。
前瞻性观察性研究。
两家生产工厂的健康志愿者。
124名女性，她们提供每日尿液样本用于测量类固醇激素和人绒毛膜促性腺激素，并提供有关酒精和咖啡因摄入量的前瞻性信息。
每100个月经周期的受孕概率。
在参与者饮酒的月经周期中，受孕概率降低了50%以上。咖啡因摄入量并未独立影响受孕概率，但可能会增强酒精的负面影响。每天戒酒且饮用少于一杯咖啡或其等量饮品的女性，每100个月经周期受孕26.9次，而每天饮酒且饮用超过一杯咖啡的女性每100个月经周期受孕10.5次。
本研究揭示了饮酒对受孕能力存在独立的剂量相关负面影响。我们的结果表明，试图受孕的女性应戒酒。
