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奎奴普丁-达福普汀对革兰氏阳性和阴性菌的抗生素后效应及抗生素后亚抑菌浓度效应

Postantibiotic effect and postantibiotic sub-MIC effect of quinupristin-dalfopristin against gram-positive and -negative organisms.

作者信息

Pankuch G A, Jacobs M R, Appelbaum P C

机构信息

Departments of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033, USA.

出版信息

Antimicrob Agents Chemother. 1998 Nov;42(11):3028-31. doi: 10.1128/AAC.42.11.3028.

DOI:10.1128/AAC.42.11.3028
PMID:9797249
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC105989/
Abstract

Quinupristin-dalfopristin produced postantibiotic effects (PAEs) and postantibiotic sub-MIC effects of >2 h against 18 gram-positive cocci. Mean pneumococcal and staphylococcal PAEs were 2.8 and 4.7 h, respectively, with shorter PAEs for constitutively than inducibly macrolide-resistant staphylococci. Mean PAEs for vancomycin-susceptible and -resistant Enterococcus faecium were 8.5 and 2.6 h, respectively.

摘要

奎奴普丁-达福普汀对18株革兰氏阳性球菌产生了抗生素后效应（PAEs）以及大于2小时的抗生素后亚抑菌浓度效应。肺炎球菌和葡萄球菌的平均PAEs分别为2.8小时和4.7小时，组成型大环内酯耐药葡萄球菌的PAEs比诱导型的短。万古霉素敏感和耐药的粪肠球菌的平均PAEs分别为8.5小时和2.6小时。

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Antimicrob Agents Chemother. 1998 Jun;42(6):1503-5. doi: 10.1128/AAC.42.6.1503.
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The pharmacokinetics of quinupristin/dalfopristin in laboratory animals and in humans.奎奴普丁/达福普汀在实验动物和人类中的药代动力学。
J Antimicrob Chemother. 1997 May;39 Suppl A:129-38. doi: 10.1093/jac/39.suppl_1.129.
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Comparative in-vitro activity of quinupristin/dalfopristin against Enterococcus spp.喹奴普丁/达福普汀对肠球菌属的体外活性比较
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Distribution of genes encoding resistance to streptogramin A and related compounds among staphylococci resistant to these antibiotics.对链阳菌素A及相关化合物耐药的葡萄球菌中编码对这些抗生素耐药性的基因分布情况。
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Antipneumococcal activities of RP 59500 (quinupristin-dalfopristin), penicillin G, erythromycin, and sparfloxacin determined by MIC and rapid time-kill methodologies.采用最低抑菌浓度（MIC）和快速杀菌方法测定RP 59500（奎奴普丁-达福普汀）、青霉素G、红霉素和司帕沙星的抗肺炎球菌活性。
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In vitro activity of RP59500, an injectable streptogramin antibiotic, against vancomycin-resistant gram-positive organisms.注射用链阳性菌素类抗生素RP59500对耐万古霉素革兰氏阳性菌的体外活性
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