Ip C
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
J Nutr. 1998 Nov;128(11):1845-54. doi: 10.1093/jn/128.11.1845.
The article reviews the progress in basic research of selenium and cancer prevention during the past decade. Special emphasis is placed on the following four major areas of discussion: 1) chemical forms of selenium and anticarcinogenic activity; 2) selenium-enriched food; 3) in vitro effects of selenite vs. monomethylated selenium; and 4) aromatic selenium compounds. It is clear that basic research has contributed new knowledge to our understanding of selenium biochemistry, anticancer efficacy and regulation of cell growth. Some of this information could be ready for incorporation into the design of a second-generation selenium trial in humans.
本文回顾了过去十年中硒与癌症预防基础研究的进展。特别强调了以下四个主要讨论领域：1）硒的化学形式与抗癌活性；2）富硒食品；3）亚硒酸盐与单甲基化硒的体外效应；4）芳香族硒化合物。显然，基础研究为我们理解硒生物化学、抗癌功效及细胞生长调控贡献了新知识。其中一些信息可用于设计第二代人体硒试验。
