Loewy A D
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Neurosci Biobehav Rev. 1998 Oct;22(6):679-84. doi: 10.1016/s0149-7634(98)00006-2.
Live viruses can be used as tools to label chains of neurons and thus to define functionally connected CNS circuits. This review summarizes the background and general principles involved in using the viral tracing technology. An attenuated form of a pig herpes virus, known as the Bartha's K strain of pseudorabies virus, has proven to be a useful type of virus for the analysis of CNS systems in the rat. The properties of this virus and the evidence for its specificity in causing trans-synaptic infections is discussed.
活病毒可作为标记神经元链的工具，从而定义功能连接的中枢神经系统回路。本综述总结了使用病毒示踪技术的背景和一般原则。一种减毒的猪疱疹病毒，即伪狂犬病病毒的巴塔株，已被证明是分析大鼠中枢神经系统的一种有用的病毒类型。本文讨论了这种病毒的特性及其引起跨突触感染的特异性证据。
