左旋咪唑治疗一名患有严重复发性口疮性口炎和中性粒细胞减少症的儿童。
Levamisole treatment of a child with severe aphthous stomatitis and neutropenia.
作者信息
Verhaegen H, De Crée J, De Cock W, Brugmans J
出版信息
Postgrad Med J. 1976 Aug;52(610):511-4. doi: 10.1136/pgmj.52.610.511.
The treatment of a 12-year-old girl with a lifelone history of recurrent infections and aphthous stomatitis is reported. A profound neutropenis, first noted at the age of 2 years, occurring at least every month was observed together with multiple mouth ulcers a sore throat and swelling of the jugular glands. Levamisole, originally described as an anthelmintic, has a beneficial effect on the symptoms of recurrent aphthous stomatitis. After levamisole treatment aphthous stomatitis was milder and in the 1-year follow-up period the patient was asymptomatic several times during a phase of obvious neutrophil depression. The child no longer complained of a sore throat with swelling of the jugular glands and the recurrent staphylococcal infections of the skin disappeared. After therapy a marked increase in monocytes at the moment of neutropenia was observed.
报告了一名12岁女孩的治疗情况，该女孩有复发性感染和阿弗他口炎的终生病史。在2岁时首次发现严重中性粒细胞减少，至少每月发生一次，同时伴有多发性口腔溃疡、喉咙痛和颈腺肿胀。左旋咪唑最初被描述为一种驱虫药，对复发性阿弗他口炎的症状有有益作用。左旋咪唑治疗后，阿弗他口炎症状较轻，在1年的随访期内，患者在明显中性粒细胞减少阶段有几次无症状。孩子不再抱怨喉咙痛和颈腺肿胀，皮肤复发性葡萄球菌感染也消失了。治疗后，在中性粒细胞减少时观察到单核细胞显著增加。
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