在编码时，海马体而非杏仁核的活动与非情感信息的长期自由回忆相关。
Hippocampal, but not amygdala, activity at encoding correlates with long-term, free recall of nonemotional information.
作者信息
Alkire M T, Haier R J, Fallon J H, Cahill L
机构信息
Department of Anesthesiology, University of California, Irvine, CA 92697-3800, USA.
出版信息
Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14506-10. doi: 10.1073/pnas.95.24.14506.
Abstract
Participation of two medial temporal lobe structures, the hippocampal region and the amygdala, in long-term declarative memory encoding was examined by using positron emission tomography of regional cerebral glucose. Positron emission tomography scanning was performed in eight healthy subjects listening passively to a repeated sequence of unrelated words. Memory for the words was assessed 24 hr later with an incidental free recall test. The percentage of words freely recalled then was correlated with glucose activity during encoding. The results revealed a striking correlation (r = 0.91, P < 0.001) between activity of the left hippocampal region (centered on the dorsal parahippocampal gyrus) and word recall. No correlation was found between activity of either the left or right amygdala and recall. The findings provide evidence for hippocampal involvement in long-term declarative memory encoding and for the view that the amygdala is not involved with declarative memory formation for nonemotional material.
摘要
通过使用区域性脑葡萄糖正电子发射断层扫描技术，研究了内侧颞叶的两个结构——海马区和杏仁核——在长期陈述性记忆编码中的参与情况。对八名健康受试者进行正电子发射断层扫描，让他们被动聆听一系列重复的不相关单词。24小时后通过偶然自由回忆测试评估对这些单词的记忆。然后将自由回忆出的单词百分比与编码过程中的葡萄糖活性进行关联。结果显示，左侧海马区（以背侧海马旁回为中心）的活性与单词回忆之间存在显著相关性（r = 0.91，P < 0.001）。在左侧或右侧杏仁核的活性与回忆之间未发现相关性。这些发现为海马体参与长期陈述性记忆编码提供了证据，也支持了杏仁核不参与非情感性材料的陈述性记忆形成这一观点。
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