Pietruska M, Pietruski J K, Stokowska W, Jabłońska E
Department of Conservative Dentistry, University Medical School, Białystok, Poland.
Arch Immunol Ther Exp (Warsz). 1998;46(5):305-9.
The paper presents the evaluation of interleukin 6 (IL-6) and interleukin 6 soluble receptor (sIL-6R) values in the blood serum of patients with various forms of periodontitis (P), as confronted with local state. The study involved a group of 15 patients with P, including 4 patients with rapidly progressive periodontitis (RPP), 10 with adult periodontitis (AP) and 1 with juvenile periodontitis (JP). The concentration of IL-6 and its soluble receptor in blood serum were assessed using the immunoenzymatic ELISA method. The clinical state was estimated with the following periodontal indices: plaque index (PI), oral hygiene index (OHI), sulcus bleeding index (SBI), probing pocket depth and probing attachment loss. The P group showed an insignificant decrease in the IL-6 level in serum and a significant increase in sIL-6R concentration, compared with controls. A correlation was found between the level of IL-6 and PI, OHI and SBI.
本文介绍了对各种形式牙周炎（P）患者血清中白细胞介素6（IL-6）和白细胞介素6可溶性受体（sIL-6R）值与局部状况进行比较的评估。该研究纳入了15名牙周炎患者，其中包括4名快速进展性牙周炎（RPP）患者、10名成人牙周炎（AP）患者和1名青少年牙周炎（JP）患者。采用免疫酶联免疫吸附测定法（ELISA）评估血清中IL-6及其可溶性受体的浓度。通过以下牙周指数评估临床状况：菌斑指数（PI）、口腔卫生指数（OHI）、龈沟出血指数（SBI）、探诊袋深度和探诊附着丧失。与对照组相比，P组血清中IL-6水平有不显著下降，而sIL-6R浓度有显著升高。发现IL-6水平与PI、OHI和SBI之间存在相关性。
