黄芩苷，一种来自黄芩的α-葡萄糖苷酶抑制剂。
Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis.
作者信息
Nishioka T, Kawabata J, Aoyama Y
机构信息
Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Kita-ku, Sapporo 060-8589, Japan.
出版信息
J Nat Prod. 1998 Nov;61(11):1413-5. doi: 10.1021/np980163p.
PMID:9834167
Abstract
Methanol extracts of Scutellaria baicalensis, Rheum officinale, and Paeonia suffruticosa showed potent inhibitory activity against rat intestinal sucrase. The active principles were identified as baicalein from the first and methyl gallate from the last two plants. In addition to its activity against the rat enzyme, baicalein also inhibited human intestinal sucrase expressed in Caco-2 cells.
摘要
黄芩、大黄和牡丹皮的甲醇提取物对大鼠肠道蔗糖酶显示出强效抑制活性。活性成分分别被鉴定为黄芩中的黄芩素以及大黄和牡丹皮中的没食子酸甲酯。除了对大鼠酶有活性外，黄芩素还抑制在Caco-2细胞中表达的人肠道蔗糖酶。
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