Kwo P Y, Ramchandani V A, O'Connor S, Amann D, Carr L G, Sandrasegaran K, Kopecky K K, Li T K
Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Gastroenterology. 1998 Dec;115(6):1552-7. doi: 10.1016/s0016-5085(98)70035-6.
BACKGROUND & AIMS: Alcoholic liver disease purportedly develops more readily in women than in men. Some studies have demonstrated faster rates of alcohol elimination in women. This study examined whether gender differences in alcohol metabolism are related to differences in liver volume and/or differences in lean body mass.
Ten men and 10 women had alcohol elimination rates determined by clamping of the breath alcohol concentration at 50 mg/dL by means of a constant rate of intravenous infusion of 6% ethanol. Liver volume was determined by computed tomography.
Mean alcohol elimination rate and mean computed liver volume were not significantly different in men and women. Lean body mass was 42% greater in men than in women. Consequently, the calculated alcohol elimination rate and liver volume per kilogram of lean body mass were 33% and 38% higher in women than in men, respectively. When the alcohol elimination rate was calculated per unit liver volume, no gender-related difference was found.
Women have greater clearance of ethanol per unit lean body mass, confirming previous oral alcohol administration studies. Women have approximately the same liver volume as men, explaining the equivalent alcohol elimination rates seen when men and women are compared on the basis of liver size.
据称，酒精性肝病在女性中比在男性中更容易发展。一些研究表明女性的酒精消除率更快。本研究调查了酒精代谢的性别差异是否与肝脏体积差异和/或瘦体重差异有关。
通过以恒定速率静脉输注6%乙醇将呼气酒精浓度钳制在50mg/dL，测定10名男性和10名女性的酒精消除率。通过计算机断层扫描测定肝脏体积。
男性和女性的平均酒精消除率和平均计算机测定的肝脏体积无显著差异。男性的瘦体重比女性大42%。因此，每千克瘦体重计算出的酒精消除率和肝脏体积女性分别比男性高33%和38%。当按单位肝脏体积计算酒精消除率时，未发现与性别相关的差异。
女性每单位瘦体重对乙醇的清除率更高，这证实了先前口服酒精给药的研究结果。女性的肝脏体积与男性大致相同，这解释了在根据肝脏大小比较男性和女性时观察到的等效酒精消除率。
