铜绿假单胞菌中的ampD基因编码AmpCβ-内酰胺酶表达的负调控因子。
An ampD gene in Pseudomonas aeruginosa encodes a negative regulator of AmpC beta-lactamase expression.
作者信息
Langaee T Y, Dargis M, Huletsky A
机构信息
Département de biologie médicale, Pavillon Marchand, Université Laval, Ste-Foy, Québec, Canada G1K 7P4.
出版信息
Antimicrob Agents Chemother. 1998 Dec;42(12):3296-300. doi: 10.1128/AAC.42.12.3296.
Abstract
The ampD and ampE genes of Pseudomonas aeruginosa PAO1 were cloned and characterized. These genes are transcribed in the same orientation and form an operon. The deduced polypeptide of P. aeruginosa ampD exhibited more than 60% similarity to the AmpD proteins of enterobacteria and Haemophilus influenzae. The ampD product transcomplemented Escherichia coli ampD mutants to wild-type beta-lactamase expression.
摘要
对铜绿假单胞菌PAO1的ampD和ampE基因进行了克隆和表征。这些基因以相同方向转录并形成一个操纵子。铜绿假单胞菌ampD推导的多肽与肠杆菌和流感嗜血杆菌的AmpD蛋白表现出60%以上的相似性。ampD产物将大肠杆菌ampD突变体互补为野生型β-内酰胺酶表达。
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