西尼罗河病毒爆发中的临床表现。

Clinical manifestations in the West Nile virus outbreak.

作者信息

Ceauşu E, Erşcoiu S, Calistru P, Ispas D, Dorobăţ O, Homoş M, Bărbulescu C, Cojocaru I, Simion C V, Cristea C, Oprea C, Dumitrescu C, Duiculescu D, Marcu I, Mociorniţă C, Stoicev T, Zolotuşca I, Calomfirescu C, Rusu R, Hodrea R, Geamai S, Păun L

机构信息

Dr. Victor Babeş Clinic of Infectious and Tropical Diseases, University of Medicine and Pharmacy, Bucharest.

出版信息

Rom J Virol. 1997 Jan-Dec;48(1-4):3-11.

PMID:9836323

Abstract

During the summer of 1996 an unusual clustering of meningoencephalitis cases was recorded in the Capital City, Bucharest, and in some areas from South-East Romania. After an initial suspicion of an enteroviral etiology was discarded, the West Nile etiology was confirmed by specific antibodies demonstration through hemagglutination-inhibition and ELISA tests. This study included 251 patients with the diagnoses of West Nile acute encephalitis (166 cases), acute meningitis (57 cases) and acute febrile disease (33 cases). The patients' age ranged from 1 to 89 years (mean 51.1 years). The most frequent clinical manifestations were: fever (95.7% of cases), cephalalgia (92.6%), stiffness of the neck (89.1%), vomiting (62.5%), marked asthenia (46.5%), myalgia (28.9%). In addition, patients with encephalitis exhibited: alteration of consciousness (89.2% of cases), tremor of extremities (40.4%), ataxia (44%), paralysis (15.1%). The fatality rate was 15.1% in acute encephalitis, 1.8% in acute meningitis and 0% in the acute febrile disease.

摘要

1996年夏天，布加勒斯特首都以及罗马尼亚东南部的一些地区记录到脑膜脑炎病例异常聚集。在最初怀疑肠道病毒病因被排除后，通过血凝抑制试验和酶联免疫吸附测定试验证实了西尼罗河病毒病因。该研究纳入了251例被诊断为西尼罗河急性脑炎（166例）、急性脑膜炎（57例）和急性发热性疾病（33例）的患者。患者年龄从1岁到89岁不等（平均51.1岁）。最常见的临床表现为：发热（95.7%的病例）、头痛（92.6%）、颈部僵硬（89.1%）、呕吐（62.5%）、明显乏力（46.5%）、肌痛（28.9%）。此外，脑炎患者还表现出：意识改变（89.2%的病例）、肢体震颤（40.4%）、共济失调（44%）、瘫痪（15.1%）。急性脑炎的死亡率为15.1%，急性脑膜炎为1.8%，急性发热性疾病为0%。